NIR-Triggered Blasting Nanovesicles for Targeted Multimodal Image-Guided Synergistic Cancer Photothermal and Chemotherapy.
NIR-Triggered Blasting Nanovesicles for Targeted Multimodal Image-Guided Synergistic Cancer Photothermal and Chemotherapy.
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DOI：
10.1021/acsami.1c08339
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发表时间：
2021-07
影响因子：
9.5
通讯作者：
Zeyu Xiao;Yuanyuan You;Yiyong Liu;Lizhen He;Dong Zhang;Qingqing Cheng;Dan Wang;Tianfeng Chen;C. Shi;L. Luo
中科院分区：
文献类型：
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作者：
Zeyu Xiao;Yuanyuan You;Yiyong Liu;Lizhen He;Dong Zhang;Qingqing Cheng;Dan Wang;Tianfeng Chen;C. Shi;L. Luo
通过纳米封装为恶性肿瘤治疗保驾护航，以改善治疗效果并减轻副作用，一直是精准医学领域的追求。然而，大多数药物递送系统都存在不可控的药物释放动力学，从而导致触发释放效率不理想以及严重的副作用。在此，我们开发了一种独特的纳米囊泡递送系统，该系统显示出近红外（NIR）光触发的药物释放行为和最小的过早药物释放。通过将超顺磁性氧化铁（SPIO）纳米颗粒、超声造影剂全氟己烷（PFH）和顺铂共同封装在硅酸盐聚苯胺囊泡中，我们以热响应方式实现了顺铂的可控释放。具体来说，近红外辐射产生的热量引发的 PFH 蒸发会给纳米囊泡带来高的内部囊泡压力，导致压力诱导的纳米囊泡塌陷和随后的顺铂释放。此外，多模态成像能力可以跟踪纳米囊泡的肿瘤参与并评估其治疗效果。由于其精确的固有近红外触发药物释放，我们的系统在体内表现出优异的肿瘤根除功效和生物相容性，使其在未来的临床转化方面具有广阔的前景。
Escorting therapeutics for malignancies by nano-encapsulation to ameliorate treatment effects and mitigate side effects has been pursued in precision medicine. However, the majority of drug delivery systems suffer from uncontrollable drug release kinetics and thus lead to unsatisfactory triggered-release efficiency along with severe side effects. Herein, we developed a unique nanovesicle delivery system that shows near-infrared (NIR) light-triggered drug release behavior and minimal premature drug release. By co-encapsulation of superparamagnetic iron oxide (SPIO) nanoparticles, the ultrasound contrast agent perfluorohexane (PFH), and cisplatin in a silicate-polyaniline vesicle, we achieved the controllable release of cisplatin in a thermal-responsive manner. Specifically, vaporization of PFH triggered by the heat generated from NIR irradiation imparts high inner vesicle pressure on the nanovesicles, leading to pressure-induced nanovesicle collapse and subsequent cisplatin release. Moreover, the multimodal imaging capability can track tumor engagement of the nanovesicles and assess their therapeutic effects. Due to its precise inherent NIR-triggered drug release, our system shows excellent tumor eradication efficacy and biocompatibility in vivo, empowering it with great prospects for future clinical translation.