REGIONS OF ALLELIC HYPERVARIABILITY IN THE MURINE-A-ALPHA IMMUNE-RESPONSE GENE
REGIONS OF ALLELIC HYPERVARIABILITY IN THE MURINE-A-ALPHA IMMUNE-RESPONSE GENE
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DOI：
10.1016/0092-8674(83)90147-2
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发表时间：
1983-01-01
期刊：
影响因子：
64.5
通讯作者：
MCDEVITT, HO
中科院分区：
文献类型：
--
作者：
BENOIST, CO;MATHIS, DJ;MCDEVITT, HO
鼠Ia抗原是一组细胞表面糖蛋白，参与免疫应答的控制。1种II类主要组织相容性复合体分子A α的结构，最近从k单倍型小鼠产生的cDNA [互补DNA]克隆的序列分析中推导出。A.alpha.从其他5种小鼠单倍型d、B、f、u和q中分离cDNA克隆并测序。序列比较显示了令人惊讶的高度等位基因多态性。氨基酸取代聚集在该多肽链的第一外部结构域内，特别是在一些高度可变的位置。A α的功能意义多态性及其可能的机制进行了讨论。
The murine Ia antigens, a group of cell surface glycoproteins, are involved in the control of the immune response. The structure of 1 class II major histocompatibility complex molecule, A.alpha., was recently deduced from sequence analysis of a cDNA [complementary DNA] clone produced from k haplotype mice. A.alpha. cDNA clones were isolated and sequenced from 5 other mouse haplotypes: d, b, f, u and q. Sequence comparison revealed a surprisingly high degree of allelic polymorphism. Amino acid substitutions were clustered within the 1st external domain of this polypeptide chain, particularly at a few highly variable positions. Functional implications of A.alpha. polymorphism and possible mechanisms for its generation are discussed.