Mast Cell-Biomaterial Interactions and Tissue Repair.
Mast Cell-Biomaterial Interactions and Tissue Repair.
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DOI：
10.1089/ten.teb.2020.0275
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发表时间：
2020-11
期刊：
影响因子：
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通讯作者：
E. Ozpinar;Ariana L. Frey;G. Cruse;D. Freytes
中科院分区：
文献类型：
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作者：
E. Ozpinar;Ariana L. Frey;G. Cruse;D. Freytes
组织工程师经常使用生物材料来提供结构支持，以及机械和化学信号来调节伤口愈合过程。植入体内的生物材料与损伤部位存在的异质和动态炎症环境相互作用。无论是人工衍生的、自然衍生的，还是两者的组合，评估生物材料调节炎症的能力以了解其潜在的临床应用是重要的。在生物材料领域，肥大细胞(MC)是一个重要但未被充分开发的细胞。MCS是粒细胞白细胞，在先天免疫系统和获得性免疫系统中都参与了各种事件。尽管MC在过敏反应中的作用得到高度认可，但它通过模式识别受体和高亲和力免疫球蛋白E受体FcεRI识别抗原，并释放影响细胞募集、纤维化、细胞外基质沉积、血管生成和血管生成的颗粒，在伤口愈合中发挥重要作用。MCS还调节异物反应，有助于植入或排斥植入物。MC-生物材料相互作用的研究有助于阐明MC在宿主组织反应中的作用。这篇综述是为组织工程和生物材料领域的那些对探索MC在伤口-生物材料相互作用和伤口愈合中可能扮演的角色感兴趣的人设计的。通过这篇综述，我们希望启发更多关于MC生物材料领域的研究，以加快优化植入物的设计和建造。
Tissue engineers often use biomaterials to provide structural support along with mechanical and chemical signals to modulate the wound healing process. Biomaterials that are implanted into the body interact with a heterogeneous and dynamic inflammatory environment that is present at the site of injury. Whether synthetically-derived, naturally-derived, or a combination of both, it is important to assess biomaterials for their ability to modulate inflammation in order to understand their potential clinical use. One important, but under-explored cell in the context of biomaterials is the mast cell (MC). MCs are granulocytic leukocytes that engage in a variety of events in both the innate and adaptive immune systems. Though highly recognized for their roles in allergic reactions, MCs play an important role in wound healing by recognizing antigens through pattern recognition receptors and the high-affinity immunoglobulin E (IgE) receptor, FcεRI, and releasing granules that affect cell recruitment, fibrosis, extracellular matrix deposition, angiogenesis, and vasculogenesis. MCs also mediate the foreign body response, contributing to the incorporation or rejection of implants. Studies of MC-biomaterial interactions can aid in the elucidation of MC roles during the host tissue response. This review is designed for those in the tissue engineering and biomaterials fields who are interested in exploring the role MCs may play in wound-biomaterial interactions and wound healing. With this review, we hope to inspire more research in the MC-biomaterial space in order to accelerate the design and construction of optimized implants.