Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy
Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy
复制标题
用于光热治疗的液态金属纳米液滴的形状控制合成
DOI：
10.1007/s12274-018-2262-y
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发表时间：
2019
期刊：
影响因子：
9.9
通讯作者：
Gu Zhen
中科院分区：
文献类型：
--
作者：
Junjie Yan;Xudong Zhang;Yang Liu;Yanqi Ye;Jicheng Yu;Qian Chen;Jinqiang Wang;Yuqi Zhang;Quanyin Hu;Yang Kang;Min Yang;Gu Zhen
水溶液中液态金属（LM）纳米滴的封端剂仅限于含硫醇且带正电的分子或大分子。然而，硫醇盐-金属络合物和静电相互作用都容易在强机械力（例如超声处理）下分离，导致稳定性和应用受到限制。为了解决这个问题，我们使用超小的水溶性黑色素纳米颗粒（MNP）作为封端剂，它与镓基LM的氧化层表现出很强的金属结合能力，从而提高了稳定性。有趣的是，LM 纳米液滴的形状控制合成可以通过掺入 MNP 来实现。通过简单地调整进料比、超声处理时间和悬浮温度，可以获得包括纳米米、纳米球和纳米棒在内的各种EGaIn纳米结构。在这些形状中，EGaIn纳米米具有最好的光热转换效率，可用于光热治疗。
The capping agents for liquid metal (LM) nanodroplets in aqueous solutions are restricted to thiol-containing and positively-charged molecules or macromolecules. However, both thiolate-metal complex and electrostatic interaction are liable to detachment upon strong mechanical forces such as sonication, leading to limited stability and applications. To address this, we utilized ultrasmall water soluble melanin nanoparticles (MNPs) as the capping agent, which exhibited strong metal binding capability with the oxide layer of gallium based LMs and resulted in enhanced stability. Interestingly, shape-controlled synthesis of LM nanodroplets can be achieved by the incorporation of MNPs. Various EGaIn nanostructures including nanorice, nanosphere and nanorod were obtained by simply tuning the feed ratio, sonication time, and suspension temperature. Among these shapes, EGaIn nanorice has the best photothermal conversion efficiency, which could be leveraged for photothermal therapy.