Electric field effects on insulin chain-B conformation
Electric field effects on insulin chain-B conformation
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DOI：
10.1021/jp052742q
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发表时间：
2005-12-01
影响因子：
3.3
通讯作者：
Yarovsky, I
中科院分区：
文献类型：
--
作者：
Budi, A;Legge, FS;Yarovsky, I
蛋白质对不同形式的应激的反应仍然是一个主要感兴趣的话题，特别是随着电磁设备的扩散被认为对人类健康具有有害影响。本文对胰岛素B链在10(7)~10(9)V/m的静电场和10(9)V/m的振荡电场作用下进行了分子动力学模拟，发现两种变异体都对蛋白质的正常行为有影响，其中振荡电场对结构的破坏比同等有效强度的静电场更大。静电场的应用对二级结构有稳定作用，限制了对胰岛素生物活性至关重要的固有灵活性。
The response of proteins to different forms of stress continues to be a topic of major interest, especially with the proliferation of electromagnetic devices conjectured to have detrimental effects on human health. In this paper, we have performed molecular dynamics simulations on insulin chain-B under the influence of both static and oscillating electric fields, ranging from 10(7) to 10(9) V/m. We have found that both variants have an effect on the normal behavior of the protein, with oscillating fields being more disruptive to the structure as compared to static fields of similar effective strength. The application of a static field had a stabilizing effect on the secondary structure, restricting the inherent flexibility that is crucial for insulin's biological activity.