Low Levels of High-Density Lipoprotein Cholesterol Predict the Presence of Coronary Artery Disease in Patients With Aortic Aneurysms
Low Levels of High-Density Lipoprotein Cholesterol Predict the Presence of Coronary Artery Disease in Patients With Aortic Aneurysms
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DOI：
10.1177/0003319713502391
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发表时间：
2014-09
期刊：
影响因子：
2.8
通讯作者：
Tatsuya Saigusa;A. Izawa;Takashi Miura;Soichiro Ebisawa;Y. Shiba;Yusuke Miyashita;T. Tomita;J. Koyama;D. Fukui;T. Takano;J. Amano;Uichi Ikeda
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文献类型：
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作者：
Tatsuya Saigusa;A. Izawa;Takashi Miura;Soichiro Ebisawa;Y. Shiba;Yusuke Miyashita;T. Tomita;J. Koyama;D. Fukui;T. Takano;J. Amano;Uichi Ikeda
为了确定主动脉瘤患者存在冠状动脉疾病(CAD)的预测因素，我们回顾了191例主动脉瘤患者的临床资料和血管造影记录(胸主动脉瘤34例，腹主动脉瘤137例，胸腹主动脉瘤20例；男性162例，平均年龄75.2±7.7岁)。冠心病的发生率为38.7%。冠心病组高密度脂蛋白胆固醇(HDLC)水平显著低于非冠心病组(45±9vs51±13 mg/dL；P=0.009)。多变量分析显示，只有低高密度脂蛋白胆固醇水平与冠心病的存在相关(调整后的优势比，0.946；95%可信区间，0.911-0.983；P=0.004)。高密度脂蛋白胆固醇预测冠心病的最佳临界值为47.50 mg/dL。冠心病在主动脉瘤患者中很常见，低水平的高密度脂蛋白胆固醇水平与冠心病的存在独立相关。
To identify predictors of the presence of coronary artery disease (CAD) in patients with planned surgery for aortic aneurysms, we reviewed clinical profiles and angiography records of 191 patients with aortic aneurysms (34 thoracic, 137 abdominal, and 20 thoracoabdominal; 162 men; mean age, 75.2 ± 7.7 years). The incidence of CAD was 38.7% among all the patients. Patients with CAD had significantly low levels of high-density lipoprotein cholesterol (HDL-C) as compared with patients without CAD (45 ± 9 vs 51 ± 13 mg/dL; P = .009). Multivariate analysis showed that only low HDL-C levels were associated with the presence of CAD (adjusted odds ratio, 0.946; 95% confidence interval, 0.911-0.983; P = .004). The optimal cutoff level of HDL-C to predict CAD was 47.50 mg/dL. The CAD is common in patients with aortic aneurysms, and low levels of HDL-C are independently associated with the presence of CAD.