Susceptibility-weighted MR imaging: A review of clinical applications in children
Susceptibility-weighted MR imaging: A review of clinical applications in children
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DOI：
10.3174/ajnr.a0786
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发表时间：
2008-01-01
影响因子：
3.5
通讯作者：
Haacke, E. M.
中科院分区：
文献类型：
--
作者：
Tong, K. A.;Ashwal, S.;Haacke, E. M.
敏感性加权成像（SWI）是一种高空间分辨率的3D梯度回波磁共振成像技术，具有相位后处理，可以突出血液制品的顺磁性，如脱氧血红蛋白、细胞内高铁血红蛋白和含铁血黄素。它对检测血管内静脉缺氧血和血管外血液制品特别有用。它对其他物质的存在也相当敏感，如铁、某些形式的钙化、末端空气。在过去的几年里，我们已经使用这种技术来研究各种各样的儿童神经系统疾病。我们回顾了一些选定的病例，以证明其在以下方面的临床应用：1)检测各种情况下的出血性病变，包括创伤性脑损伤、凝血功能障碍或其他出血性疾病；2)检测血管畸形，如海绵状血管瘤、毛细血管扩张或与斯特奇-韦伯综合征相关的颅底血管瘤；3)在梗死、缺氧/缺氧损伤或脑死亡的情况下出现静脉血栓形成和/或吸氧增加；4)肿瘤伴有出血、钙化或血管增强的描述；5)神经退行性疾病中钙或铁沉积的描述。SWI为其中一些疾病过程提供了新的认识。希望随着社会福利指数变得更加广泛，它将提供更多的诊断和预后信息，从而改善受影响儿童的护理和结果。
Susceptibility-weighted imaging (SWI) is a high-spatial-resolution 3D gradient-echo MR imaging technique with phase postprocessing that accentuates the paramagnetic properties of blood products such as deoxyhemoglobin, intracellular methemoglobin, and hemosiderin. It is particularly useful for detecting intravascular venous deoxygenated blood as well as extravascular blood products. It is also quite sensitive to the presence of other substances such as iron, some forms of calcification, End air. We have used this technique in the past several years to study a wide variety of pediatric neurologic disorders. We present a review with selected case histories to demonstrate its clinical usefulness in the improvement of the following: 1) detection of hemorrhagic lesions seen in various conditions, including traumatic brain injury and coagulopathic or other hemorrhagic disorders; 2) detection of vascular malformations such as cavernous angiomas, telangiectasias, or pial angiomas associated with Sturge-Weber syndrome; 3) demonstration of venous thrombosis and/or increased oxygen extraction in the setting of infarction, hypoxic/anoxic injury, or brain death; 4) delineation of neoplasms with hemorrhage, calcification, or increased vascularity; and 5) depiction of calcium or iron deposition in neurodegenerative disorders. SWI has provided new understanding of some of these disease processes. It is hoped that as SWI becomes more widely available, it will provide additional diagnostic and prognostic information that will improve the care and outcome of affected children.