Androgen receptors in a Syrian hamster ductus deferens tumour cell line
Androgen receptors in a Syrian hamster ductus deferens tumour cell line
复制标题
叙利亚仓鼠输精管肿瘤细胞系中的雄激素受体
作者：
J. Norris;J. Gorski;P. Kohler
我们已经在培养中建立了一个克隆的仓鼠输精管细胞系，其中含有一种饱和的、高亲和力的睾酮受体蛋白。这些细胞在睾酮和5α-二氢睾酮（DHT）治疗下表现出更高的DNA合成率，尽管它们可能不需要任何一种雄激素来生存。我们相信这是第一个克隆细胞系对生理剂量的雄激素表现出生长反应的描述。类固醇的作用机制可能与正常组织中的作用机制相似。
WE have established in culture a cloned line of hamster ductus deferens cells that contains a saturable, high affinity testosterone receptor protein. These cells exhibit an increased rate of DNA synthesis in response to testosterone and 5α-dihydrotestosterone (DHT) treatment, although they probably do not require either androgen for survival. We believe this is the first description of a cloned cell line that exhibits a growth response to a physiological dose of androgen. The mechanism of action of the steroid may be similar to that in the normal tissue of origin.