Involvement of P-glycoprotein and cytochrome P450 3A in the metabolism of florfenicol of rabbits
Involvement of P-glycoprotein and cytochrome P450 3A in the metabolism of florfenicol of rabbits
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DOI：
10.1111/j.1365-2885.2011.01310.x
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发表时间：
2012-04-01
影响因子：
1.3
通讯作者：
Jiang, S. -X.
中科院分区：
文献类型：
--
作者：
Liu, N.;Guo, M.;Jiang, S. -X.
本文探讨了细胞色素P450 3A(CyP3A)和P-糖蛋白(P-gp)参与广谱抗生素氟苯尼考(EFC)在兔体内代谢过程的研究。本研究选用新西兰白兔20只，随机分为4组，分别饲喂颗粒状饲料和自由饮水。结果证实P-gp和CyP3A与FFC共同参与了其在兔体内的沉积。
The article discusses a study on the involvement of cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp) in the metabolic process of a broad-spectrum antibiotic known as florfenicol (EFC) in rabbits. The study uses 20 white male rabbits from New Zealand feed with palleted feed, water ad libitum and divided into four groups. Results confirmed the involvement of P-gp and CYP3A with FFC in its deposition in rabbits.