Trans-generational effects of prenatal stress in quail
Trans-generational effects of prenatal stress in quail
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DOI：
10.1098/rspb.2012.2368
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发表时间：
2013-02-22
影响因子：
4.7
通讯作者：
Houdelier, Cecilia
中科院分区：
文献类型：
--
作者：
Guibert, Floriane;Lumineau, Sophie;Houdelier, Cecilia
产前环境是影响动物特征的表型变异的一个来源。产前应激不仅影响子代的发育，而且影响下一代的发育。这种影响在哺乳动物中得到了最好的记录，但在鸟类中也可以观察到，这表明了跨系统发育顺序的共同过程。我们之前发现，日本鹌鹑雌性在产卵时受到压力会产生更高的恐惧，这可能与卵子中睾酮水平的调节有关。在这里，我们通过分析这些F-1后代的生殖特征，然后分析它们随后（F-2）后代的发育，来评估产前压力的长期影响。F-1产前应激雄鼠的性行为受到损害。F1PS雌卵的蛋黄含量较F-1雌卵低，蛋白含量较高，卵黄酮和孕酮水平较高。F-2产前应激鹌鹑的恐惧程度大于F-2产前对照鹌鹑。这些F-2行为差异与他们的父母所证明的相似，表明产前压力效应的跨代传递，可能是由F1PS雌性的卵子成分介导的。
The prenatal environment is a source of phenotypic variability influencing the animal's characteristics. Prenatal stress affects not only the development of offspring, but also that of the following generation. Such effects have been best documented in mammals but can also be observed in birds, suggesting common processes across phylogenetic orders. We found previously that Japanese quail females stressed during laying produced offspring with higher fearfulness, probably related to modulation of testosterone levels in their eggs. Here, we evaluated long-term effects of prenatal stress by analysing reproductive traits of these F-1 offspring and, then, the development of their subsequent (F-2) offspring. The sexual behaviour of F-1 prenatally stressed (F1PS) males was impaired. F1PS females' eggs contained less yolk and more albumen, and higher yolk testosterone and progesterone levels than did F-1 prenatal control females. The fearfulness of F-2 prenatally stressed quail was greater than that of F-2 prenatal control quail. These F-2 behavioural differences paralleled those evidenced by their parents, suggesting trans-generational transmission of prenatal stress effects, probably mediated by egg compositions of F1PS females.