When two wrongs make a right: synchronized neuronal bursting from combined electrical and inhibitory coupling
When two wrongs make a right: synchronized neuronal bursting from combined electrical and inhibitory coupling
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DOI：
10.1098/rsta.2016.0282
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发表时间：
2017-06
期刊：
影响因子：
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通讯作者：
R. Reimbayev;K. Daley;I. Belykh
中科院分区：
文献类型：
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作者：
R. Reimbayev;K. Daley;I. Belykh
哺乳动物中枢神经系统中的同步皮质活动对于感觉知觉、协调和运动功能至关重要。在新皮层中产生同步突触输入的神经元机制远未被完全理解。在本文中，我们研究了同步的出现在网络的爆裂神经元作为一个高度非平凡的，电气和抑制连接的综合效果。我们报告了一个违反直觉的发现，结合电和抑制耦合可以协同诱导强大的同步在一系列参数，其中电耦合单独促进反相尖峰和抑制诱导反相爆裂。我们揭示了潜在的机制，它使用的电和抑制耦合的隐藏属性之间的平衡，共同作用，以同步神经元的爆发。我们表明，这种平衡是由占空比的自耦合系统，管理同步突发节奏。这篇文章是“医学中的数学方法：神经科学，心脏病学和病理学”主题问题的一部分。
Synchronized cortical activities in the central nervous systems of mammals are crucial for sensory perception, coordination and locomotory function. The neuronal mechanisms that generate synchronous synaptic inputs in the neocortex are far from being fully understood. In this paper, we study the emergence of synchronization in networks of bursting neurons as a highly non-trivial, combined effect of electrical and inhibitory connections. We report a counterintuitive find that combined electrical and inhibitory coupling can synergistically induce robust synchronization in a range of parameters where electrical coupling alone promotes anti-phase spiking and inhibition induces anti-phase bursting. We reveal the underlying mechanism, which uses a balance between hidden properties of electrical and inhibitory coupling to act together to synchronize neuronal bursting. We show that this balance is controlled by the duty cycle of the self-coupled system which governs the synchronized bursting rhythm. This article is part of the themed issue ‘Mathematical methods in medicine: neuroscience, cardiology and pathology’.