RISK-FACTORS FOR PROGRESSIVE SUPRANUCLEAR PALSY
RISK-FACTORS FOR PROGRESSIVE SUPRANUCLEAR PALSY
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DOI：
10.1212/wnl.38.10.1546
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发表时间：
1988-10-01
期刊：
影响因子：
9.9
通讯作者：
SCHOENBERG, BS
中科院分区：
文献类型：
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作者：
DAVIS, PH;GOLBE, LI;SCHOENBERG, BS
为了探讨进行性核上性麻痹（PSP）可能的危险因素，我们在美国新泽西州对50例患者进行了病例对照研究。两名神经科医生在41名在世患者中证实了这一诊断。两个医院对照按年龄、性别、种族、死亡日期和每个病例的近亲关系进行匹配。对病例和对照组的近亲进行了结构化访谈。研究了遗传、病毒、毒性、医学、外科和人格因素。病例成年生活在人口稀少地区的频率明显高于对照组。该研究没有发现与PSP相关的其他因素，包括中风史、高血压史或吸烟史。
To explore possible risk factors for progressive supranuclear palsy (PSP), we conducted a case-control study of 50 cases in New Jersey, (USA). Two neurologists confirmed the diagnosis in the 41 living patients. Two hospital controls were matched by age, sex, race, date of death, and relationship of next-to-kin to each case. A structured interview was administered in person to the next-to-kin of cases and controls. Genetic, viral, toxic, medical, surgical, and personality factors were investigated. Cases lived in areas with low population as adults significantly more frequently than controls. The study identified no other factors associated with PSP including a history of stroke, hypertension, or smoking.