Airway tight junctions as targets of viral infections.
Airway tight junctions as targets of viral infections.
复制标题
作为病毒感染靶点的气道紧密连接。
DOI：
10.1080/21688370.2021.1883965
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发表时间：
2021-04-03
期刊：
影响因子：
3.1
通讯作者：
Rezaee F
中科院分区：
文献类型：
--
作者：
Linfield DT;Raduka A;Aghapour M;Rezaee F
呼吸道上皮细胞的顶端连接复合体(AJCs)是先天性免疫系统的关键组成部分，它对病原体、吸入性过敏原和环境颗粒物产生屏障。AJCs形成于相邻细胞之间，由紧密连接(TJ)和附着连接(AJ)组成。呼吸道病毒已被证明针对AJCs的各种成分，通过不同的机制导致呼吸道上皮屏障功能障碍。病毒诱导的上皮通透性可能允许过敏原和细菌病原体随后入侵。在这篇综述中，我们讨论了导致AJCs破坏的病理生理学机制及其潜在的后续影响。我们专注于以下影响肺部系统的病毒：呼吸道合胞病毒、鼻病毒、流感病毒、免疫缺陷病毒以及其他病毒，如柯萨奇病毒、腺病毒、冠状病毒、麻疹、副流感病毒、博卡病毒和牛痘病毒。了解病毒以AJC为靶点并损害屏障功能的机制可能有助于设计治疗这些感染的治疗创新。
The apical junctional complexes (AJCs) of airway epithelial cells are a key component of the innate immune system by creating barriers to pathogens, inhaled allergens, and environmental particles. AJCs form between adjacent cells and consist of tight junctions (TJs) and adherens junctions (AJs). Respiratory viruses have been shown to target various components of the AJCs, leading to airway epithelial barrier dysfunction by different mechanisms. Virus-induced epithelial permeability may allow for allergens and bacterial pathogens to subsequently invade. In this review, we discuss the pathophysiologic mechanisms leading to disruption of AJCs and the potential ensuing ramifications. We focus on the following viruses that affect the pulmonary system: respiratory syncytial virus, rhinovirus, influenza viruses, immunodeficiency virus, and other viruses such as coxsackievirus, adenovirus, coronaviruses, measles, parainfluenza virus, bocavirus, and vaccinia virus. Understanding the mechanisms by which viruses target the AJC and impair barrier function may help design therapeutic innovations to treat these infections.