A mutation in the C-elegans EXP-2 potassium channel that alters feeding behavior
A mutation in the C-elegans EXP-2 potassium channel that alters feeding behavior
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DOI：
10.1126/science.286.5449.2501
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发表时间：
1999-12-24
期刊：
影响因子：
56.9
通讯作者：
Avery, L
中科院分区：
文献类型：
--
作者：
Davis, MW;Fleischhauer, R;Avery, L
线虫咽部有一个具有不同寻常特性的钾通道，它允许肌肉以适当的延迟快速重极化。在这里，秀丽隐杆线虫的exp-2基因被证明编码这个通道。EXP-2是一种kv型（电压激活）钾通道，具有向内整流特性，类似于结构不同的人类以太-go-go相关基因（HERG）通道。无效和功能获得突变以与通道的电生理行为一致的方式影响咽肌兴奋性，从而证明了这种不寻常通道的动力学和行为之间的直接联系。
The nematode pharynx has a potassium channel with unusual properties, which allows the muscles to repolarize quickly and with the proper delay. Here, the Caenorhabditis elegans exp-2 gene is shown to encode this channel. EXP-2 is a Kv-type (voltage-activated) potassium channel that has inward-rectifying properties resembling those of the structurally dissimilar human ether-a-go-go-related gene (HERG) channel. Null and gain-of-function mutations affect pharyngeal muscle excitability in ways that are consistent with the electrophysiological behavior of the channel, and thereby demonstrate a direct Link between the kinetics of this unusual channel and behavior.