F4/80 and the related adhesion-GPCRs
F4/80 and the related adhesion-GPCRs
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DOI：
10.1002/eji.201141715
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发表时间：
2011-09-01
影响因子：
5.4
通讯作者：
Stacey, Martin
中科院分区：
文献类型：
--
作者：
Gordon, Siamon;Hamann, Joerg;Stacey, Martin
F4/80单克隆抗体30年前首次在该杂志中报道（Eur. J. Immunol.1981. 11：805-815）。F4/80已成为小鼠中单核细胞和许多但不是全部组织巨噬细胞的广泛使用的标志物。F4/80是白细胞质膜七螺旋分子的EGF-TM 7家族的成员，其包括CD 97和EMR 2。该观点总结了EGF-TM 7家族的表达，结构和功能的当前知识，作为组织粘连-GPCR更大家族的一部分。
The F4/80 monoclonal antibody was first reported in this journal 30 years ago (Eur. J. Immunol. 1981. 11: 805-815). F4/80 has become a widely used marker for monocytes and many, but not all, tissue macrophages in the mouse. F4/80 is a member of the EGF-TM7 family of leukocyte plasma membrane heptahelical molecules, which includes CD97 and EMR2. This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF-TM7 family, as part of a larger family of tissue adhesion-GPCRs.