Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity
Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity
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DOI：
10.1101/lm.253506
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发表时间：
2006-09-01
影响因子：
2
通讯作者：
Malinow, Roberto
中科院分区：
文献类型：
--
作者：
Boehm, Jannic;Ehrlich, Ingrid;Malinow, Roberto
GluR1 的调节运输对突触可塑性有显着贡献，但针对 GluR1 C 末端 PDZ 配体结构域在此过程中的功能的研究产生了相互矛盾的结果。在这里，我们通过证明明显相似的 GluR1 PDZ 配体结构域 C 端突变在活动和 CamKII 诱导的突触可塑性过程中导致相反的生理表型来解决这一冲突。
The regulated trafficking of GluR1 contributes significantly to synaptic plasticity, but studies addressing the function of the GluR1 C-terminal PDZ-Iigand domain in this process have produced conflicting results. Here, we resolve this conflict by showing that apparently similar C-terminal mutations of the GluR1 PDZ-ligand domain result in opposite physiological phenotypes during activity- and CamKII-induced synaptic plasticity.