The transcriptome of cerebral ischemia.
The transcriptome of cerebral ischemia.
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DOI：
10.1016/j.brainresbull.2012.02.002
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发表时间：
2012-07-01
影响因子：
3.8
通讯作者：
Barr TL
中科院分区：
文献类型：
--
作者：
VanGilder RL;Huber JD;Rosen CL;Barr TL
中风的分子因果关系和反应是复杂的。然而，许多研究中风分子反应的文献都集中在已经很好表征的靶向途径上。因此，自从近十年前组织纤溶酶原激活剂被批准用于治疗以来，我们对中风病理生理的理解在临床治疗方面几乎没有取得进展。缺乏临床翻译的部分原因是由于以神经元为中心的研究，脑缺血的临床前模型和神经炎症的矛盾性质。随着中风治疗学术行业圆桌会议标准的发展，简化研究工作和基因组技术的广泛可用性，破译缺血性中风分子指纹的能力即将出现。本文重点介绍了缺血性脑的临床前微阵列研究结果，讨论了脑预处理的转录组，并强调了进一步表征神经血管单位和外周白细胞在半暗带介导中风损伤和修复中的作用的重要性。
The molecular causality and response to stroke is complex. Yet, much of the literature examining the molecular response to stroke has focused on targeted pathways that have been well-characterized. Consequently, our understanding of stroke pathophysiology has made little progress by way of clinical therapeutics since tissue plasminogen activator was approved for treatment nearly a decade ago. The lack of clinical translation is in part due to neuron-focused studies, preclinical models of cerebral ischemia and the paradoxical nature of neuro-inflammation. With the evolution of the Stroke Therapy Academic Industry Roundtable criteria streamlining research efforts and broad availability of genomic technologies, the ability to decipher the molecular fingerprint of ischemic stroke is on the horizon. This review highlights preclinical microarray findings of the ischemic brain, discusses the transcriptome of cerebral preconditioning and emphasizes the importance of further characterizing the role of the neurovascular unit and peripheral white blood cells in mediating stroke damage and repair within the penumbra.