Studies of radon and lung cancer in North America and China
Studies of radon and lung cancer in North America and China
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DOI：
10.1093/oxfordjournals.rpd.a006194
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发表时间：
2003-01-01
影响因子：
1
通讯作者：
Lubin, JH
中科院分区：
文献类型：
--
作者：
Lubin, JH
对氡暴露的地下矿工的研究表明，住宅氡是肺癌的第二大原因。在北美进行了7项住宅氡的病例对照研究，在中国进行了2项，代表了这些地区的所有研究，其中包括200例或更多肺癌病例，并使用了长期氡探测器。北美研究入组4081例病例和5281例对照，中国研究入组1076例病例和2015例对照。基于对汇总数据的分析，100 Bq m（-3）时，北美研究的优势比（OR）和95%置信限为1.106（1.00，1.28），中国研究为1.139（1.01，1.37）。群体内OR的同质性检验不显著。在访谈前5-30年暴露期内完成剂量测定的受试者中，北美研究中100 Bq m（-3）的OR为1.205（1.03，1.50），中国研究中为1.279（1.07，0.75）。结果与矿工的推断是一致的，并表明住宅氡的肺癌风险过高。
Studies of radon-exposed underground miners indicate that residential radon is the second leading cause of lung cancer. Seven case-control studies of residential radon have been conducted in North America and two in China, and represent all studies in these areas which included 200 or more lung cancer cases and used long-term radon detectors. North American studies enrolled 4081 cases and 5281 controls, and Chinese studies enrolled 1076 cases and 2015 controls. Based on analyses of pooled data, odds ratios (ORs) and 95% confidence limits at 100 Bq m(-3) were 1.106 (1.00,1.28) for the North American studies and 1.139 (1.01,1.37) for the Chinese studies. Tests of homogeneity of ORs within populations were not significant. Among subjects with complete dosimetry for the 5-30 y exposure period prior to interview, ORs at 100 Bq m(-3) were 1.205 (1.03,1.50) for the North American studies and 1.279 (1.07,0.75) for the Chinese studies. Results are consistent with extrapolations from miners and indicate an excess lung cancer risk from residential radon.