Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway
Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway
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DOI：
10.1089/jir.1998.18.549
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发表时间：
1998-08-01
影响因子：
2.3
通讯作者：
Darnell, JE
中科院分区：
文献类型：
--
作者：
Darnell, JE
1997年秋天，与乔治·R·斯塔克和伊恩·M·克尔分享了米尔斯坦奖，邀请他们记录下对我们关于干扰素作用机制的实验的个人反思。我们以及克尔和斯塔克实验室的工作揭示了Jak-Stat通路，通过该通路，来自细胞表面受体的信号到达细胞核中的基因。这篇评论集中在我可以最可靠地谈论的事情上，也就是我在洛克菲勒大学年轻的同事们所做的实验。
Sharing the Milstein Award with George R. Stark and Ian M. Kerr in the fall of 1997 brought this invitation to record personal reflections on our experiments concerning the mechanisms of action of interferon. Our work and that of the Kerr and Stark laboratories uncovered the Jak-Stat pathway through which signals from cell surface receptors reach genes in the cell nucleus. This review concentrates on that to which I can speak most reliably, that is, experiments done by my young colleagues at Rockefeller University.