Metabolism of the anthracycline antibiotic daunorubicin to daunorubicinol and deoxydaunorubicinol aglycone in hepatocytes isolated from the rat and the rabbit.
Metabolism of the anthracycline antibiotic daunorubicin to daunorubicinol and deoxydaunorubicinol aglycone in hepatocytes isolated from the rat and the rabbit.
复制标题
蒽环类抗生素柔红霉素在大鼠和兔肝细胞中代谢为柔红霉素和脱氧柔红霉素苷元。
DOI：
10.1016/0006-2952(86)90028-6
复制
发表时间：
1986
影响因子：
5.8
通讯作者：
Yanovich,S
中科院分区：
文献类型：
--
作者：
Gewirtz,DA;Yanovich,S
In the rat and rabbit hepatocyte in suspension, daunorubicin was metabolized primarily to deoxydaunorubicinol aglycone and daunorubicinol. Little deoxydaunorubicin aglycone was observed in either species. High levels of daunorubicinol in the rabbit hepatocyte reflected the greater affinity of rabbit hepatic aldo-keto reductase for the substrate, daunorubicin. Conjugates of the anthracyclines were not observed with hepatocytes from either species. The relative formation of deoxydaunorubicinol aglycone and deoxydaunorubicin aglycone suggests that daunorubicinol is a preferred substrate for reductive deglycosidation. Consequently, the presence of daunorubicinol in the circulation of patients undergoing chemotherapy with daunorubicin may be a factor in the therapeutic efficacy of this antineoplastic agent.
