NEUTROPHIL AGGREGATION INDUCED BY SERA FROM PATIENTS WITH ACTIVE SYSTEMIC LUPUS-ERYTHEMATOSUS
NEUTROPHIL AGGREGATION INDUCED BY SERA FROM PATIENTS WITH ACTIVE SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1002/art.1780260509
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发表时间：
1983-01-01
影响因子：
--
通讯作者：
WEISSMANN, G
中科院分区：
文献类型：
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作者：
ABRAMSON, SB;GIVEN, WP;WEISSMANN, G
活化的补体成分和免疫复合物在体外和体内引起中性粒细胞（PMN）聚集，如透析诱导的中性粒细胞减少症和成人呼吸窘迫综合征。为探讨中性粒细胞（PMN）聚集在系统性红斑狼疮（SLE）中的可能作用，对53例SLE患者的59份血清在体外诱导正常PMN聚集的能力进行了研究。28例活动期SLE患者中有26例血清中存在神经元聚集活性（NAA）。该组的平均NAA显著高于13例非活动期SLE患者、20例类风湿关节炎患者和17例正常对照者。在SLE患者中，疾病严重程度与NAA的定量测量呈正相关。NAA与血清C3 [补体成分3]或C4也不与循环免疫复合物的存在或不存在相关。高水平的NAA是中枢神经系统狼疮的特征。血管内白细胞聚集体的形成可能是SLE发病的原因之一。
Activated complement components and immune complexes cause neutrophil (PMN) aggregation in vitro and in vivo, as in dialysis-induced neutropenia and adult respiratory distress syndrome. To investigate the possible role of PMN aggregation in systemic lupus erythematosus (SLE), the capacity of 59 sera from 53 patients to induce aggregation of normal PMN in vitro was studied. Neutrophil aggregating activity (NAA) was present in the sera of 26 of 28 patients with active SLE. The mean NAA in this group was significantly greater than that found in 13 patients with inactive SLE, 20 patients with rheumatoid arthritis, and 17 normal controls. In patients with SLE there was a positive correlation between disease severity and the quantitative measure of NAA. NAA did not correlate with serum C3 [complement component 3] or C4 nor with the presence or absence of circulating immune complexes. High levels of NAA were particularly characteristic of CNS lupus. The formation of intravascular leukoaggregates may contribute to morbidity in SLE.