Maintenance of heterochromatin by RNA interference of tandem repeats
Maintenance of heterochromatin by RNA interference of tandem repeats
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DOI：
10.1038/ng1252
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发表时间：
2003-11-01
期刊：
影响因子：
30.8
通讯作者：
Martienssen, RA
中科院分区：
文献类型：
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作者：
Martienssen, RA
串联重复序列容易发生由RNA干扰调控的表观遗传沉默。这可能是因为来自串联阵列转录本的sirna被RNA依赖性RNA聚合酶（RdRP）和Dicer再生，但来自单拷贝序列的sirna被RdRP连续使用下游引物耗尽。这可以解释从串联重复序列形成异染色质的原因。
Tandem repeats are prone to epigenetic silencing regulated by RNA interference. This may be because siRNAs from tandem array transcripts are regenerated by RNA-dependent RNA polymerase (RdRP) and Dicer, but siRNAs from single-copy sequences are exhausted by sequential use of downstream primers by RdRP. This could account for the formation of heterochromatin from tandem repeats.