Streptozotocin-induced deficits in sex behavior and neuroendocrine function in male rats.
Streptozotocin-induced deficits in sex behavior and neuroendocrine function in male rats.
复制标题
链脲佐菌素诱导雄性大鼠性行为和神经内分泌功能缺陷。
DOI：
10.1210/endo-124-4-1737
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发表时间：
1989
期刊：
影响因子：
4.8
通讯作者：
M. Smith
中科院分区：
文献类型：
--
作者：
R. Steger;A. Amador;Eric Lam;J. Rathert;J. Weis;M. Smith
观察链脲佐菌素(STZ)诱导的糖尿病对成年雄性大鼠神经内分泌和性功能的影响。成年雄性大鼠注射链脲佐菌素(50 mg/kg)或赋形剂，分别于7、14、21天后进行交配行为测试。在STZ或赋形剂治疗1个月后处死大鼠，测定血浆激素水平、下丘脑儿茶酚胺转换率、LHRH含量和体外垂体功能。STZ大鼠在坐位、插入和射精行为方面表现出明显的缺陷。STZ组大鼠血浆睾酮、黄体生成素、卵泡刺激素和催乳素水平均显著低于对照组，但体外促黄体生成素分泌增加。在体外，两组PRL的分泌和对多巴胺的抑制反应没有差异。STZ治疗后，下丘脑内侧基底核(MBH)LHRH水平降低，而正中隆起(ME)和下丘脑前部(AH)LHRH水平无明显变化。与赋形剂对照组相比，STZ组大鼠ME、MBH和AH的去甲肾上腺素转换率降低，ME组的多巴胺转换率无明显变化，MBH组的多巴胺转换率增加，AH组的多巴胺转换率降低。这些结果表明，STZ治疗糖尿病大鼠的垂体和睾丸功能的变化是继发于下丘脑儿茶酚胺代谢的变化。交配行为的变化可能是由于血浆睾酮水平的降低以及中枢神经递质代谢的变化。
The effects of streptozotocin-induced (STZ) diabetes on neuroendocrine and sexual function were evaluated in adult male rats. Adult male rats were injected with STZ (50 mg/kg) or vehicle and tested for copulatory behavior 7, 14, and 21 days later. The rats were killed 1 month after STZ or vehicle treatment for measurement of plasma hormone levels, hypothalamic catecholamine turnover, LHRH content, and in vitro pituitary function. The STZ rats showed significant deficits in mount, intromission, and ejaculatory behaviors. Plasma levels of testosterone, LH, FSH, and PRL were all significantly reduced in the STZ compared to the control rats, but in vitro LH secretion was enhanced after STZ treatment. In vitro PRL secretion and the inhibitory response to dopamine did not differ between the two groups. The levels of LHRH were reduced in the medial basal hypothalamus (MBH), but LHRH levels in the median eminence (ME) and anterior hypothalamus (AH) were unchanged after STZ treatment. Norepinephrine turnover was reduced in the ME, MBH, and AH of the STZ rats, while dopamine turnover was unchanged in the ME, increased in the MBH, and reduced in the AH of the STZ rats compared to those in the vehicle-treated controls. These results suggest that changes in pituitary and testicular function in rats made diabetic by STZ treatment are secondary to changes in hypothalamic catecholamine metabolism. Changes in copulatory behavior could be due to both reductions in plasma testosterone levels as well as changes in central neurotransmitter metabolism.