Neurally triggered breaths reduce trigger delay and improve ventilator response times in ventilated infants with bronchiolitis
Neurally triggered breaths reduce trigger delay and improve ventilator response times in ventilated infants with bronchiolitis
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DOI：
10.1007/s00134-011-2352-8
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发表时间：
2011-11-01
影响因子：
38.9
通讯作者：
Heulitt, Mark J.
中科院分区：
文献类型：
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作者：
Clement, Katherine C.;Thurman, Tracy L.;Heulitt, Mark J.
目的：神经调节呼吸辅助（纳瓦）是一种通气模式，旨在通过解释来自横膈膜的神经信号以触发支持呼吸来改善患者-呼吸机交互。我们假设神经触发呼吸可以减少毛细支气管炎患儿的触发延迟、呼吸机响应时间和呼吸功。研究方法：在交叉设计中，对临床诊断为毛细支气管炎的受试者进行容量支持（气动触发）和纳瓦（气动和神经触发）研究。使用呼吸速度描记器和计算机化数字记录仪获得气道流量和压力波形，并记录每次实验120 s。结果：神经触发呼吸的触发延迟（ms）较短（40 +/- 27 vs. 98 +/- 34; p
Purpose: Neurally adjusted ventilatory assist (NAVA) is a mode of ventilation designed to improve patient-ventilator interaction by interpreting a neural signal from the diaphragm to trigger a supported breath. We hypothesized that neurally triggered breaths would reduce trigger delay, ventilator response times, and work of breathing in pediatric patients with bronchiolitis. Methods: Subjects with a clinical diagnosis of bronchiolitis were studied in volume support (pneumatic trigger) and NAVA (pneumatic and neural trigger) in a crossover design. Airway flow and pressure waveforms were obtained with a pneumotachograph and computerized digital recorder and were recorded for 120 s for each experiment. Results: Neurally triggered breaths had less trigger delay (ms) (40 +/- 27 vs. 98 +/- 34; p