The biological features and prognosis of breast cancer diagnosed during pregnancy: A case-control study
The biological features and prognosis of breast cancer diagnosed during pregnancy: A case-control study
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DOI：
10.3109/0284186x.2011.636069
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发表时间：
2012-05-01
期刊：
影响因子：
3.1
通讯作者：
Peccatori, Fedro A.
中科院分区：
文献类型：
--
作者：
Azim, Hatem A., Jr.;Botteri, Edoardo;Peccatori, Fedro A.
背景资料。妊娠期乳腺癌(BCP)是一种相对罕见的疾病，在生物学和预后方面存在争议。因此，我们设计了一项病例对照研究，以检查在同一机构诊断和治疗的一系列BCP患者的肿瘤特征和结果。材料和方法。我们确定了65名被诊断为BCP的患者，每名患者；我们选择了两名非妊娠乳腺癌患者，他们在年龄、手术年份、分期和新辅助化疗方面匹配。然后，我们比较了病理、免疫组织化学特征(ER、PR、HER2和Ki-67)、无病(DFS)和总生存期(OS)的差异。结果。我们没有发现两组之间在肿瘤特征上的任何显著差异。然而，在中位数四年的随访中，BCP患者在调整可能的混杂协变量后有较低的DFS(HR 2.3；95%CI 1.3-4.2)。在OS方面没有观察到差异。然而，将分析局限于未接受新辅助化疗的患者后，BCP患者的OS也较差(HR 2.6；95%CI 1.0-6.5)。未观察到引产与预后之间的关系。结论。虽然我们没有观察到任何肿瘤特征的差异，但与年龄和分期匹配的对照组相比，BCP患者的预后更差。进一步的研究应该试图阐明如此糟糕的结果的原因。
Background. Breast cancer during pregnancy (BCP) is relatively rare and is associated with controversies about its biology and prognosis. Hence, we designed a case-control study to examine tumor features and outcome in a series of BCP patients diagnosed and treated in a single institution. Material and methods. We identified 65 patients diagnosed with BCP and for each; we selected two non-pregnant breast cancer patients, who were matched for age, year of surgery, stage, and neoadjuvant chemotherapy. We then compared the differences in pathology, immunohistochemical features (ER, PR, HER2 and ki-67), disease-free (DFS) and overall survival (OS). Results. We did not find any significant differences in tumor characteristics between the two groups. However, at a median follow-up of four years, BCP patients had an inferior DFS (HR 2.3; 95% CI 1.3-4.2), after adjustment for possible confounding covariates. No difference in OS was observed. However, upon restricting the analysis to patients who did not receive neoadjuvant chemotherapy, patients with BCP had inferior OS as well (HR 2.6; 95% CI 1.0-6.5). No association between induction of abortion and prognosis was observed. Conclusions. While we did not observe any differences in tumor features, BCP patients have poorer prognosis compared to age and stage-matched control. Further studies should try to elucidate reasons for such poor outcome.