GABA and muscimol as reversible inactivation tools in learning and memory.
GABA and muscimol as reversible inactivation tools in learning and memory.
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GABA和MUSCIMOL是学习和记忆中可逆的灭活工具。
DOI：
10.1155/np.2000.19
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发表时间：
2000
影响因子：
3.1
通讯作者：
Di Scala G
中科院分区：
文献类型：
--
作者：
Majchrzak M;Di Scala G
脑区可逆失活是推断脑-行为关系的有效方法。输注GABA或GABA受体激动剂muscimol被认为是一种有趣的可逆失活方法，因为它可能不影响通道纤维，因此可以与保留轴突类型的病变进行比较。本文对该方法在学习记忆实验中获得的数据进行了综述。对与Simon Brailowsky合作收集的慢性GABA输注数据进行了批判性分析，并提供了肌肉醇诱导失活获得的数据说明。
Reversible inactivation of brain areas is a useful method for inferring brain-behavior relationships. Infusion of GABA or of the GABA receptor agonist muscimol is considered one interesting reversible inactivation method because it may not affect fibers of passage and may therefore be compared to axon-sparing types of lesions. This article reviews the data obtained with this method in learning and memory experiments. A critical analysis of data, collected in collaboration with Simon Brailowsky, with chronic GABA infusion is presented, together with an illustration of data obtained with muscimol-induced inactivation.