AAO: Autoimmune and Autoinflammatory (Disease) in Otology: What is New in Immune-Mediated Hearing Loss.
AAO: Autoimmune and Autoinflammatory (Disease) in Otology: What is New in Immune-Mediated Hearing Loss.
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DOI：
10.1002/lio2.28
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发表时间：
2016-10
影响因子：
1.9
通讯作者：
Pathak, Shresh
中科院分区：
文献类型：
--
作者：
Vambutas, Andrea;Pathak, Shresh
自身炎症性疾病是一类免疫介导的罕见疾病，其中一些表现为感音神经性听力损失（SNHL），这表明自身炎症介导的听力损失和自身免疫性内耳疾病（AIED）之间可能存在潜在相似的分子发病机制。本综述的目的是比较影响听力的自身免疫性和自身炎症性疾病的临床特征，讨论我们知识的局限性，并突出潜在的新疾病机制和治疗方法。Pubmed文献综述;谷歌学术文献综述。AIED与一些表现为感音神经性听力损失的自身炎症性疾病进行了重点比较。这些疾病的发病机制进行了审查的背景下，先天性和适应性免疫系统，细胞因子的表达和遗传多态性。自Cogan和Lehnhardt首次描述AIED并由McCabe首次临床表征以来，AIED一直是一种神秘的疾病，在新诊断和新治疗方面的进展有限。自发现自身炎性疾病以来，许多系统性自身免疫性疾病被重新归类为自身炎性疾病或被鉴定为具有自身炎性疾病的特征。AIED具有自身免疫性和自身炎症性疾病的临床特征。正确识别自身炎症性疾病至关重要，因为如果不这样做，可能会导致系统性淀粉样变性和肾损伤。
Autoinflammatory diseases are a family of immune‐mediated, rare diseases, some of which, exhibit sensorineural hearing loss (SNHL), suggesting potentially similar mechanisms of molecular pathogenesis between autoinflammatory‐mediated hearing loss and autoimmune inner ear disease (AIED) may exist. The purpose of this review is to compare the clinical features of autoimmune and autoinflammatory diseases that affect hearing, discuss the limitations of our knowledge, and highlight potential new disease mechanisms and therapeutics. Pubmed Literature Review; Google Scholar Literature review. A focused comparison of AIED with a number of autoinflammatory diseases that manifest with sensorineural hearing loss was performed. The pathogenesis of these diseases is reviewed in the context of the innate and adaptive immune system, cytokine expression and genetic polymorphisms. AIED, since first described by Cogan and Lehnhardt and first clinically characterized by McCabe, has remained an enigmatic disease, with limited advances in both new diagnostics and new therapeutics. Since the discovery of autoinflammatory diseases, a number of systemic autoimmune diseases have either been re‐classed as autoinflammatory diseases or identified to have features of autoinflammatory disease. AIED has clinical features of both autoimmune and autoinflammatory disease. It is critical that autoinflammatory diseases be correctly identified, as failure to do so may result in systemic amyloidosis and kidney damage.