Effects of opioid microinjections into the medial septal area on spatial memory in rats.
Effects of opioid microinjections into the medial septal area on spatial memory in rats.
复制标题
内侧间隔区阿片类药物微注射对大鼠空间记忆的影响。
DOI：
10.1037//0735-7044.102.5.643
复制
发表时间：
1988
影响因子：
1.9
通讯作者：
King,RA
中科院分区：
文献类型：
--
作者：
Bostock,E;Gallagher,M;King,RA
最近的工作表明，训练后全身阿片拮抗剂管理促进收购的径向臂迷宫任务在新的空间环境。在这项研究中，我们研究了训练后向内侧隔区微量注射纳洛酮和β-内啡肽对在新空间环境中获得径向迷宫任务的影响。这些实验的结果表明，训练后隔内纳洛酮给药促进，而训练后隔内β-内啡肽给药损害，在新的空间环境中进行的迷宫任务的标准性能的收购。此外，脑室内β-内啡肽给药未产生与隔内β-内啡肽给药后观察到的效应相当的效应，这表明隔区是对阿片类药物对新环境中空间记忆效应敏感的脑部位。此外，在熟悉的空间环境中，训练后隔内注射β-内啡肽对工作记忆没有影响，而训练前隔内注射β-内啡肽对先前获得的空间任务的表现没有影响。
Recent work has demonstrated that posttraining systemic opioid antagonist administration facilitates the acquisition of a radial arm maze task in new spatial environments. In this study, we examined the effect of posttraining naloxone and β-endorphin microinjections into the medial septal area on the acquisition of a radial maze task in new spatial environments. The results of these experiments demonstrated that posttraining intraseptal naloxone administration facilitated, whereas posttraining intraseptal β-endorphin administration impaired, the acquisition of criterion performance on a maze task performed in new spatial environments. Further, intraventricular β-endorphin administration did not produce effects that were comparable to those observed following intraseptal β-endorphin administration, which indicates that the septal region is a brain site that is sensitive to the effects of opioids on spatial memory in new environments. Further, posttraining intraseptal β-endorphin administration had no effect on working memory in a familiar spatial environment, whereas pretraining intraseptal β-endorphin administration had no effect on the performance of a previously acquired spatial task.