TISSUE-RESPONSE TO BIPHASIC CALCIUM-PHOSPHATE CERAMIC WITH DIFFERENT RATIOS OF HA/BETA-TCP IN PERIODONTAL OSSEOUS DEFECTS
TISSUE-RESPONSE TO BIPHASIC CALCIUM-PHOSPHATE CERAMIC WITH DIFFERENT RATIOS OF HA/BETA-TCP IN PERIODONTAL OSSEOUS DEFECTS
复制标题
DOI：
10.1902/jop.1992.63.9.729
复制
发表时间：
1992-09-01
影响因子：
4.3
通讯作者：
LEE, K
中科院分区：
文献类型：
--
作者：
NERY, EB;LEGEROS, RZ;LEE, K
本研究的目的是确定双相多孔磷酸钙（BCP）陶瓷中羟基磷灰石（HA）和β磷酸三钙（β TCP）的最佳比例，以有效修复牙周骨缺损。通过手术在比格犬中产生缺损，并使其慢性化4个月以模拟牙周病。采用牙周粘骨膜瓣翻转，然后进行骨缺损清创和根面平整术。将具有不同HA/betaTCP比例的特殊制备的陶瓷植入到制备的缺损中。使部位愈合6个月，对动物实施安乐死，并取出部位块进行组织学研究。在随访阶段，每月进行一次刮治和抛光，并在术前和术后6个月记录标准化的探测附着水平。邓肯氏多重范围检验表明，所有处理组的探测附着水平均显著高于对照组（OHA/ObetaTCP）（P
THE PURPOSE OF THIS STUDY was to determine the optimal ratio of calcium hydroxyapatite (HA) to beta tricalcium phosphate (betaTCP) in a biphasic porous calcium phosphate (BCP) ceramic for effective repair of periodontal osseous defects. Defects were surgically produced in beagle dogs and made chronic for 4 months to simulate periodontal disease. Mucoperiosteal periodontal flaps were reflected, followed by osseous defect debridement and root planing. Specially prepared ceramic with different HA/betaTCP ratios were implanted into the prepared defects. The sites were allowed to heal for 6 months, animals were euthanized, and site-blocks were removed for histological study. During the follow-up phase, scaling and polishing were done once a month, and standardized probing attachment levels were recorded pre- and 6-months postoperatively. The Duncan's multiple range test showed that all the treatments produced statistically significant higher gain in probing attachment levels than the control group (OHA/ObetaTCP) (P