The effect of acute phencyclidine administration on cyclopropane requirement (MAC) in rats.
The effect of acute phencyclidine administration on cyclopropane requirement (MAC) in rats.
复制标题
急性苯环己哌啶给药对大鼠环丙烷需求（MAC）的影响。
DOI：
10.1097/00000542-198204000-00008
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发表时间：
1982
期刊：
影响因子：
8.8
通讯作者：
DiFazio,CA
中科院分区：
文献类型：
--
作者：
Raja,SN;Moscicki,JC;WoodsideJr,JR;DiFazio,CA
研究了大鼠急性给药苯环利定对麻醉需氧量（MAC）的影响。用环丙烷麻醉大鼠，用尾钳法测定MAC值。PCP（2或4 mg/kg）皮下注射分别使环丙烷MAC降低32%和42%。PCP诱导的MAC降低未被纳洛酮治疗改变，这表明PCP不太可能与阿片类药物机制相互作用。在这些单胺衰竭的大鼠中，4 mg/kg PCP使MAC进一步降低22%。在用利血平和α -甲基-对酪氨酸预处理几乎完全耗尽儿茶酚胺的大鼠中，观察到MAC显著（43%）下降。在这些缺乏儿茶酚胺的大鼠中，给药2mg /kg的PCP使MAC减少了10%，总MAC减少了53%。PCP对单胺和儿茶酚胺缺乏的大鼠的影响表明，虽然对中枢单胺的影响可能在PCP的作用机制中起作用，但它不是药物的唯一作用模式。在被PCP麻醉的患者中，由于麻醉需求可能比未被麻醉的患者少得多，因此麻醉过量的可能性很大。
The effect of acute administration of phencyclidine (PCP) on the anesthetic requirement (MAC) was studied in rats. Rats were anesthetized with cyclopropane and MAC determinations were made by the tail-clamp technique. PCP, 2 or 4 mg/kg, subcutaneously, produced a 32 and 42 per cent decrease, respectively, in cyclopropane MAC. The PCP-induced decrease in MAC was not altered by naloxone treatment indicating that an interaction of PCP with opiate mechanisms is unlikely. Central monoamine depletion with reserpine decreased cyclopropane MAC by 20 per cent. In these monoamine-depleted rats, 4 mg/kg PCP produced a further reduction in MAC of 22 per cent. In rats almost totally depleted of catecholamines by pretreatment with reserpine and alpha-methyl-p-tyrosine, a marked (43 per cent) decrease in MAC was observed. The administration of 2 mg/kg PCP, in these catecholamine-depleted rats produced an additional 10 per cent decrease in MAC for a total reduction in MAC of 53 per cent. The effect of PCP in the monoamine-and catecholamine-depleted rats indicates that while an effect on central monoamines may play a part in the mechanism of action of PCP, it is not the sole mode of action of the drug. In patients intoxicated with PCP there is a significant potential for anesthetic overdose as their anesthetic requirement may be much less than would be expected in the nonintoxicated state.