Clinical significance of extraintestinal Hafnia alvei isolates from 61 patients and review of the literature
Clinical significance of extraintestinal Hafnia alvei isolates from 61 patients and review of the literature
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DOI：
10.1093/clinids/22.6.1040
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发表时间：
1996-06-01
影响因子：
11.8
通讯作者：
Pennekamp, A
中科院分区：
文献类型：
--
作者：
Gunthard, H;Pennekamp, A
蜂房哈夫尼菌是一种革兰氏阴性细菌，很少从人体标本中分离出来，也很少被认为是致病性的。它与胃肠炎、脑膜炎、菌血症、肺炎、医院伤口感染、眼内炎和眼脓肿有关。我们研究了80 H。在30个月内从61名患者中回收了肺泡分离物。H.从包括呼吸道（n = 38）、胃肠道（n = 16）和泌尿生殖道（n = 12）的部位培养肺泡;在血液培养物（n = 8）、中心静脉导管（n = 3）和皮肤（n = 3）上发现微生物。只有25%的H.在纯培养物中回收肺泡分离物。57例（93.4%）患者有基础疾病，H。alvei被证明是两次败血症和一次腹膜炎的病原体，并可能导致另外两名患者的败血症和一名患者的肺炎。所有6例患者在接受抗生素治疗和/或标准手术治疗后（如需要）均痊愈。这些感染中有3例是医院感染，3例是社区获得性感染。对H.在我们的研究中测试的肺泡，100%对奈替米星、环丙沙星和亚胺培南敏感; 92%对哌拉西林敏感; 90%对复方新诺明敏感; 88%对头孢曲松和头孢他啶敏感。在这项研究中，我们发现H。肺泡是医院和社区获得性感染的一种罕见但重要的病原体。
Hafnia alvei is a gram-negative bacterium that is rarely isolated from human specimens and is rarely considered to be pathogenic. It has been associated with gastroenteritis, meningitis, bacteremia, pneumonia, nosocomial wound infections, endophthalmitis, and a buttock abscess. We studied 80 H. alvei isolates recovered from 61 patients within a period of 30 months. H. alvei was cultured from sites that included the respiratory tract (n = 38), the gastrointestinal tract (n = 16), and the urogenital tract (n = 12); the organism was found in blood cultures (n = 8), on central venous catheters (n = 3), and on the skin (n = 3). Only 25% of H. alvei isolates were recovered in pure cultures. Fifty-seven (93.4%) of the patients had an underlying illness, H. alvei proved to be the etiologic agent in two episodes of septicemia and in one episode of peritonitis and was probably responsible for septicemia in two other patients and pneumonia in one. All six of these patients recovered after receiving antibiotic treatment and/or standard surgical treatment, when needed. Three of these infections were nosocomial, and three were community acquired. Of the strains of H. alvei tested in our study, 100% were susceptible to netilmicin, ciprofloxacin, and imipenem; 92% were susceptible to piperacillin; 90% were susceptible to co-trimoxazole; and 88% were susceptible to ceftriaxone and ceftazidime. In this study, we found H. alvei to be a rare but significant etiologic agent of nosocomial and community-acquired infections.