Plasma ascorbic acid concentrations and fat distribution in 19068 British men and women in the European Prospective Investigation into Cancer and Nutrition Norfolk cohort study
Plasma ascorbic acid concentrations and fat distribution in 19068 British men and women in the European Prospective Investigation into Cancer and Nutrition Norfolk cohort study
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DOI：
10.1093/ajcn/82.6.1203
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发表时间：
2005-12-01
影响因子：
7.1
通讯作者：
Khaw, KT
中科院分区：
文献类型：
--
作者：
Canoy, D;Wareham, N;Khaw, KT
背景：抗氧化剂，如抗坏血酸，在清除自由基以防止氧化性内皮损伤中发挥作用。过量的脂肪可能会促进脂肪酸氧化，增加自由基浓度，这可能会导致抗氧化剂的使用增加。血浆抗坏血酸浓度是否与脂肪分布相关仍不清楚。目的：我们的目的是检查一般人群中腹部肥胖（通过腰臀比测量）与血浆抗坏血酸浓度之间的相关性。设计：我们检查了十字架-19068名45岁以下男女的人体测量脂肪分布与血浆抗坏血酸浓度之间的截面关系79岁，没有已知的慢性病。膳食抗坏血酸摄入量估计为一个亚组的8178名男性和女性保持7天的食物日记编码为nutrientintake.Results：腰臀比呈负相关的男性和女性的血浆抗坏血酸浓度。这种关联与体重指数、年龄、维生素补充剂的使用、吸烟和社会经济群体无关。腰围和臀围与血浆抗坏血酸浓度呈独立和相反的相关性，与体重指数和其他协变量无关。饮食中的抗坏血酸摄入量只能部分解释所观察到的associations.Conclusions：血浆抗坏血酸与脂肪分布无关的体重指数。饮食摄入量和生活习惯的差异，潜在的全身氧化应激，或两者兼而有之，可以解释脂肪分布和血浆抗坏血酸浓度之间的反比关系。需要进一步的研究来确定这些观察结果的潜在解释。
Background: Antioxidants, such as ascorbic acid, play a role in scavenging free radicals to protect against oxidative endothelial damage. Excess fat may promote fatty acid oxidation and increase free radical concentrations, which could result in increased antioxidant use. Whether plasma ascorbic acid concentrations are associated with fat distribution remains unclear.Objective: Our aim was to examine the association between abdominal obesity, as measured by the waist-to-hip ratio, and plasma ascorbic acid concentrations in the general population.Design: We examined the cross-sectional relation between anthropometric measurements of fat distribution and plasma ascorbic acid concentrations in 19 068 men and women aged 45-79 y without known chronic illness. Dietary ascorbic acid intake was estimated for a subgroup of 8178 men and women who kept 7-d food diaries coded for nutrient intake.Results: The waist-to-hip ratio was inversely related to plasma ascorbic acid concentrations in both men and women. This association was independent of body mass index, age, vitamin supplement use, cigarette smoking, and socioeconomic group. Waist and hip circumferences showed separate and opposite associations with plasma ascorbic acid concentrations, independent of body mass index and other covariates. Dietary ascorbic acid intake only partly explained the observed associations.Conclusions: Plasma ascorbic acid was associated with fat distribution independent of body mass index. Differences in dietary intake and lifestyle habits, underlying systemic oxidative stress, or both may explain the inverse relation between fat distribution and plasma ascorbic acid concentrations. Additional studies are needed to determine the underlying explanation of these observations.