Cefuroxime-associated Kounis syndrome with unique peculiarity in perioperative prophylaxis
Cefuroxime-associated Kounis syndrome with unique peculiarity in perioperative prophylaxis
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头孢呋辛相关的 Kounis 综合征在围手术期预防中具有独特性
DOI：
10.1016/j.jiph.2018.02.009
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发表时间：
2018-11-01
影响因子：
6.7
通讯作者：
Ma, Jingjing
中科院分区：
文献类型：
--
作者：
Gao, Jie;Gao, Yuan;Ma, Jingjing
头孢呋辛是一种广谱抗菌剂，用于围手术期预防。库尼斯综合征被定义为过敏性事件与急性冠状动脉综合征同时发生。围手术期预防头孢呋辛相关Kounis综合征的数据有限。我们报告的情况下，37岁的妇女接受双侧汗腺切除术谁提出了库尼斯综合征后头孢呋辛输注围手术期预防。患者有严重的症状和以前从未报道过的独特表现：粉红色泡沫痰表明心力衰竭，由于严重的收缩功能障碍，需要有创通气和主动脉内球囊反搏。头孢呋辛相关的库尼斯综合征有几个独特的和危及生命的特点，这拓宽了我们对临床和实验室特征的理解。对于医生来说，在围手术期预防头孢呋辛可能出现的心血管并发症是很重要的。(C) 2018年作者。由爱思唯尔有限公司代表沙特国王本阿卜杜勒阿齐兹健康科学大学出版。这是一篇基于CC BY-NC-ND许可的开放获取文章
Cefuroxime is a broad spectrum antibacterial agent administered in cases of perioperative prophylaxis. Kounis syndrome is defined as the concurrence of anaphylactic events with acute coronary syndromes. Limited data is available for cefuroxime-associated Kounis syndrome in perioperative prophylaxis. We report the case of a 37-year-old woman undergoing bilateral sweat gland resection who presented with Kounis syndrome following cefuroxime infusion for perioperative prophylaxis. The patient had severe symptoms and unique manifestations that never been reported before: pink frothy sputum indicating heart failure, due to severe systolic dysfunction requiring invasive ventilation and intra-aortic balloon counter-pulsation. Cefuroxime-associated Kounis syndrome has several unique and life-threatening peculiarities which broaden our understanding of clinical and laboratory characteristics. It is important for physicians to be aware of possible cardiovascular complications in perioperative cefuroxime prophylaxis. (C) 2018 The Authors. Published by Elsevier Limited on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license