CLINICAL CHARACTERISTICS OF ILLNESS CAUSED BY BORDETELLA-PARAPERTUSSIS COMPARED WITH ILLNESS CAUSED BY BORDETELLA-PERTUSSIS
CLINICAL CHARACTERISTICS OF ILLNESS CAUSED BY BORDETELLA-PARAPERTUSSIS COMPARED WITH ILLNESS CAUSED BY BORDETELLA-PERTUSSIS
复制标题
DOI：
10.1097/00006454-199404000-00011
复制
发表时间：
1994-04-01
影响因子：
3.6
通讯作者：
CHERRY, JD
中科院分区：
文献类型：
--
作者：
HEININGER, U;STEHR, K;CHERRY, JD
结合德国的百日咳疫苗效力试验，从1992年5月至1993年3月从咳嗽疾病患者中收集鼻咽标本。临床数据通过初始和随访问卷获得。从38例患者（平均年龄3.5岁，68%为女孩）中分离出副百日咳杆菌。并与同期76例年龄、性别相匹配的百日咳杆菌感染病例进行比较。结果为：（B.百日咳/B。副百日咳）：咳嗽> 4周57%/37%（P = 0.06）;喘息80%/59%（P = 0.07）; whoop> 2周26%/18%（P = 0.05）;发作90%/83%（P = 0.5）;体温大于或等于38 ℃ 9%/0%（P = 0.17）;呕吐47%/42%白细胞和淋巴细胞平均计数分别为12500/mm3和7600/mm3（P <0.0001）及7800/mm3和3500/mm3（P <0.0001）。由B引起的疾病。副百日咳是典型的百日咳，但不如B引起的严重。百日咳。与B相反。百日咳感染时，淋巴细胞增多不是B的特征。副百日咳感染。这很可能是由于B缺乏淋巴细胞生成促进因子毒素。副百日咳。
In conjunction with a pertussis vaccine efficacy trial in Germany, nasopharyngeal specimens were collected from May, 1992, to March, 1993, from patients with cough illnesses. Clinical data were obtained by initial and follow-up questionnaires. Bordetella parapertussis was isolated from 38 patients (mean age, 3.5 years; 68% girls). Clinical characteristics in these cases were compared with those of 76 patients (matched by age and sex) with illness caused by Bordetella pertussis during the same period. Findings were: (B. pertussis/B. parapertussis): cough > 4 weeks 57%/37% (P = 0.06); whoop 80%/59% (P = 0.07); whoop > 2 weeks 26%/18% (P = 0.05); paroxysms 90%/83% (P = 0.5); body temperature greater than or equal to 38 degrees C 9%/0% (P = 0.17); vomiting 47%/42% (P = 0.69); and mean leukocyte and lymphocyte counts 12 500/mm(3) and 7600/mm(3) (P < 0.0001) and 7800/mm(3) and 3500/mm(3) (P < 0.0001), respectively. Illness caused by B. parapertussis was typical of pertussis but less severe than that caused by B. pertussis. In contrast with B. pertussis infection, lymphocytosis is not a characteristic of B. parapertussis infection. This is most likely a result of the lack of production of lymphocytosis-promoting factor toxin by B. parapertussis.