Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses
Specifying a target trial prevents immortal time bias and other self-inflicted injuries in observational analyses
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DOI：
10.1016/j.jclinepi.2016.04.014
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发表时间：
2016-11-01
影响因子：
7.2
通讯作者：
Shrier, Ian
中科院分区：
文献类型：
--
作者：
Hernan, Miguel A.;Sauer, Brian C.;Shrier, Ian
许多对观察数据的分析都是为了模拟目标试验。当研究人员偏离指导随机实验设计和分析的简单原则时，目标试验的模拟可能会失败。我们回顾了一个描述和预防偏倚的框架，包括不朽的时间偏倚，它是由于未能调整随访开始，资格说明和治疗分配而导致的。我们回顾了一些分析方法，以避免在比较有效性或安全性研究中出现这些问题。(C) 2016 Elsevier Inc.版权所有。
Many analyses of observational data are attempts to emulate a target trial. The emulation of the target trial may fail when researchers deviate from simple principles that guide the design and analysis of randomized experiments. We review a framework to describe and prevent biases, including immortal time bias, that result from a failure to align start of follow-up, specification of eligibility, and treatment assignment We review some analytic approaches to avoid these problems in comparative effectiveness or safety research. (C) 2016 Elsevier Inc. All rights reserved.