Improvement of resolution for brain coupled metabolites by optimized 1H MRS at 7 T
Improvement of resolution for brain coupled metabolites by optimized 1H MRS at 7 T
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DOI：
10.1002/nbm.1529
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发表时间：
2010-11-01
影响因子：
2.9
通讯作者：
Maher, Elizabeth A.
中科院分区：
文献类型：
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作者：
Choi, Changho;Dimitrov, Ivan E.;Maher, Elizabeth A.
据报道，在7T上通过Te-optimed点分辨光谱法（PRESS）在7T中的谷氨酸（GLU），谷氨酰胺（GIN）和谷胱甘肽（GSH）的分辨率增强，据报道GLU，GSH，GSH，GSH，GSH，GSH，GSH，GSH，GSH，GSH，GSH， 2 2-2 6 ppm的γ-氨基丁酸（GABA）和N-乙酰天冬氨酸（NAA）使用密度矩阵模拟研究，结合了三维体积定位。数值模拟表明，由于多重缩小和多重组的变窄，C4质子多重组可以与（TE1，TE2）=（37，63）MS完全分开。 NAA 2 5 ppm信号幻象实验的抑制作用在体内测试中的模拟中复制了信号的产量和线形。通过LCMODEL，GLU，GIN和GSH的LCMODEL，CRAMER-RAO下边界（CRLB）在六个健康志愿者拟合中的六位健康志愿者的前额叶皮层上进行了优化的压力（平均+/- SD），分别为评估相同实验条件下优化新闻方法的性能，用（TE，TE，TE， tm）=（14，37）和（74，68）MS MS GLU的婴儿床在压力机和短Te刺激的回声采集模式（Steam）之间相似，但是杜松子酒和GSH的CRLB在Press中都低于这两个中的CRLB蒸汽采集版权所有（C）2010 John Wiley＆Sons，Ltd
Resolution enhancement for glutamate (Glu), glutamine (Gin) and glutathione (GSH) in the human brain by TE-optimized point-resolved spectroscopy (PRESS) at 7T is reported Sub-TE dependences of the multiplets of Glu, Gln, GSH, gamma-aminobutyric acid (GABA) and N-acetylaspartate (NAA) at 2 2-2 6 ppm were investigated with density matrix simulations, incorporating three-dimensional volume localization The numerical simulations indicated that the C4 proton multiplets can be completely separated with (TE1, TE2) = (37, 63) ms, as a result of a narrowing of the multiplets and suppression of the NAA 2 5 ppm signal Phantom experiments reproduced the signal yield and lineshape from simulations within experimental errors In vivo tests of optimized PRESS were conducted on the prefrontal cortex of six healthy volunteers In spectral fitting by LCModel, Cramer-Rao lower bounds (CRLBs) of Glu, Gin and GSH were 2 +/- 1, 5 +/- 1 and 6 +/- 2 (mean +/- SD), respectively To evaluate the performance of the optimized PRESS method under identical experimental conditions, stimulated-echo spectra were acquired with (TE, TM) = (14, 37) and (74, 68) ms The CRIB of Glu was similar between PRESS and short-TE stimulated-echo acquisition mode (STEAM), but the CRLBs of Gin and GSH were lower in PRESS than in both STEAM acquisitions Copyright (C) 2010 John Wiley & Sons, Ltd