On the modeling of mechanotransduction in flow-mediated dilation.
On the modeling of mechanotransduction in flow-mediated dilation.
复制标题
关于血流介导的扩张中的机械传导的建模。
DOI：
10.1016/j.jmbbm.2021.104606
复制
发表时间：
2021
影响因子：
3.9
通讯作者：
Wu,Qianhong
中科院分区：
文献类型：
--
作者：
Sidnawi,Bchara;Chen,Zhen;Sehgal,Chandra;Santhanam,Sridhar;Wu,Qianhong
In this paper, we report a physics based mathematical model to describe the mechanotransduction at the luminal surface of the brachial artery during a flow-mediated dilation (FMD) process. To account for the effect of the released vasodilators in response to the sudden blood flow resurgence, a scalar property is introduced as a signal radially diffusing through the arterial wall, locally affecting its compliance. The model was evaluated on 19in vivoresponses of brachial artery FMD (BAFMD) in 12 healthy subjects. It successfully reproduces the time-dependent dilation of the brachial artery. The predicted artery's outer-to-inner radius ratio was also found to be consistent with the measurements within an acceptable margin of error. Physically meaningful dimensionless parameters quantifying the artery's physical state arose from the model, providing a description to how sensitive or responsive the artery is to the changes of wall shear stress (WSS). Future applications of this model, via incorporating inexpensive, relatively quick, and non-invasive imaging, could potentially help detect early stages of developing forms of cardiovascular diseases.
