THE BASOLATERAL AMYGDALA VENTRAL STRIATAL SYSTEM AND CONDITIONED PLACE PREFERENCE - FURTHER EVIDENCE OF LIMBIC STRIATAL INTERACTIONS UNDERLYING REWARD-RELATED PROCESSES
THE BASOLATERAL AMYGDALA VENTRAL STRIATAL SYSTEM AND CONDITIONED PLACE PREFERENCE - FURTHER EVIDENCE OF LIMBIC STRIATAL INTERACTIONS UNDERLYING REWARD-RELATED PROCESSES
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DOI：
10.1016/0306-4522(91)90145-e
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发表时间：
1991-01-01
期刊：
影响因子：
3.3
通讯作者：
ROBBINS, TW
中科院分区：
文献类型：
--
作者：
EVERITT, BJ;MORRIS, KA;ROBBINS, TW
研究了双侧兴奋性毒性氨基酸诱导的杏仁核基底外侧区损伤、腹侧纹状体损伤，或这两种结构的不对称单侧损伤对条件性位置偏爱表达的影响。通过在独特环境中让饥饿的大鼠接触蔗糖来形成位置偏爱。在获得偏爱后，双侧使君子酸诱导的杏仁核基底外侧区损伤以及双侧喹啉酸诱导的腹侧纹状体损伤消除了条件性位置偏爱。双侧喹啉酸诱导的尾壳核腹内侧（而非背外侧）损伤减弱了位置偏爱。将杏仁核基底外侧区的单侧损伤与腹侧纹状体的对侧损伤相结合也破坏了条件性位置偏爱。这些数据进一步支持了杏仁核基底外侧区和腹侧纹状体是支持刺激 - 奖赏关联的神经系统的重要组成部分这一假设。
The effects on the expression of a conditioned place preference of bilateral, excitotoxic amino acid-induced lesions of the basolateral region of the amygdala, or the ventral striatum, or asymmetric, unilateral lesions of both structures were studied. The place preference was conditioned by exposing hungry rats to sucrose in a distinctive environment. Following acquisition, bilateral quisqualate-induced lesions of the basolateral amygdala, as well as bilateral quinolinate-induced lesions of the ventral striatum, abolished the conditioned place preference. Bilateral ventromedial, but not dorsolateral, quinolinate-induced caudate-putamen lesions attenuated the place preference. Combining a unilateral lesion of the basolateral amygdala with a contralateral lesion of the ventral striatum also disrupted the conditioned place preference.These data provide further support for the hypothesis that the basolateral amygdala and ventral striatum are important parts of a neural system subserving stimulus-reward associations.