Genistein induces Gadd45 gene and G2/M cell cycle arrest in the DU145 human prostate cancer cell line
Genistein induces Gadd45 gene and G2/M cell cycle arrest in the DU145 human prostate cancer cell line
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DOI：
10.1016/j.febslet.2004.09.085
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发表时间：
2004-11-05
期刊：
影响因子：
3.5
通讯作者：
Sakai, T
中科院分区：
文献类型：
--
作者：
Oki, T;Sowa, Y;Sakai, T
金雀异黄素是大豆中含量最丰富的异黄酮类化合物，已被证明在各种人类癌细胞系中会导致生长停滞。然而，实现这一目标的确切机制仍不清楚。我们报道了金雀异黄素通过其启动子在人前列腺癌DU145细胞系中诱导了生长停滞和DNA损伤诱导基因45(GADD45)基因。转录因子核因子-Y与GADD45启动子的CCAAT位点的结合似乎对金雀异黄素的激活很重要。(C)2004年欧洲生化学会联合会。爱思唯尔出版，版权所有。
Genistein is the most abundant isoflavone of soybeans and has been shown to cause growth arrest in various human cancer cell lines. However, the precise mechanism for this is still unclear. We report here that the growth arrest and DNA damage-inducible gene 45 (gadd45) gene is induced by genistein via its promoter in a DU145 human prostate cancer cell line. The binding of transcription factor nuclear factor-Y to the CCAAT site of the gadd45 promoter appears to be important for this activation by genistein. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.