'Idiopathic' eosinophilia with an occult T-cell clone: Prevalence and clinical course
'Idiopathic' eosinophilia with an occult T-cell clone: Prevalence and clinical course
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DOI：
10.1016/j.leukres.2006.10.005
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发表时间：
2007-05-01
影响因子：
2.7
通讯作者：
Pardanani, A.
中科院分区：
文献类型：
--
作者：
Vaklavas, C.;Tefferi, A.;Pardanani, A.
在一项对99名特发性嗜酸性粒细胞增多症患者的研究中，在14名患者的血液、骨髓或其他组织样本中发现了克隆性T细胞，其中6名患者有明显的T细胞恶性肿瘤。其余8名患者(类似于8%)的T细胞克隆不明显，主要是皮肤病，所有6名可评估的患者中都没有F1P1L1-PDGFRA。两名患者接受了小剂量环磷酰胺或甲氨蝶呤的有效治疗，而格列卫(R)治疗另外两名患者无效。2例(25%)在嗜酸性前驱症状3-8年后转化为皮肤T细胞淋巴瘤。(C)2006爱思唯尔有限公司。保留所有权利。
In a study of 99 consecutive patients with 'idiopathic' eosinophilia, clonal T-cells were demonstrated in blood, bone marrow, or other tissue samples of 14 patients including 6 who had an overt T-cell malignancy. The remaining eight patients (similar to 8%) with an 'Occult' T-cell clone had predominantly cutaneous disease and F1P1L1-PDGFRA was absent in all six evaluable patients. Two patients were effectively treated with low-dose oral cyclophosphamide or methotrexate whereas Gleevec (R) treatment was ineffective in another two patients. Two patients (25%) transformed into cutaneous T-cell lymphoma after 3-8 years of eosinophilic prodrome. (c) 2006 Elsevier Ltd. All rights reserved.