Standardizing the measurement of intraocular pressure for clinical research - Guidelines from the eye care technology forum
Standardizing the measurement of intraocular pressure for clinical research - Guidelines from the eye care technology forum
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DOI：
10.1016/s0161-6420(96)30741-0
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发表时间：
1996-01-01
期刊：
影响因子：
13.7
通讯作者：
Kass, MA
中科院分区：
文献类型：
--
作者：
Kass, MA
背景虽然有许多不同的仪器可用于测量眼内压（IOP），但Goldmann眼压计是国际”金标准“。“Goldmann眼压计的优点包括：技术成熟，设备广泛可用，技术安全且易于执行，测量结果相当准确且可重复。然而，Goldmann眼压计也有一些局限性。可能主要的局限性是IOP是青光眼性视力丧失的次要或替代终点。此外，IOP通常以昼夜模式波动。在健康个体中，昼夜变化范围为3至6 mmHg，但青光眼或高眼压个体的波动要大得多。关于Goldmann眼压计的准确性的数据有限。影响测量准确性的主要因素是角膜厚度。在薄角膜中，Goldmann眼压测量法在20 mmHg的水平下将IOP低估了约5 mmHg。在厚角膜中，Goldmann眼压测量法在30 mmHg时高估IOP多达7 mmHg。
BackgroundAlthough there are many different instruments available for measuring intraocular pressure (lOP), the Goldmann tonometer is the international" gold standard." The advantages of Goldmann tonometry include the following: the technique is well established, the equipment is widely available, the technique is safe and easy to perform, and the measurements are fairly accurate and reproducible. However, there are a number oflimitations to Goldmann tonometry as well. Perhaps the major limitation is that lOP is a secondary or surrogate endpoint for glaucomatous visual loss. In addition, lOP typically fluctuates in a diurnal pattern. In healthy individuals, the diurnal variation ranges from 3 to 6 mmHg but the fluctuation is far greater in individuals with glaucoma or ocular hypertension. There are limited data on the accuracy of Goldmann tonometry. The major factor affecting the accuracy of the measurement is corneal thickness. I, 2 In thin corneas Goldmann tonometry underestimates lOP by as much a~ 5 mmHg at a level of 20 mmHg. In thick corneas, Goldmann tonometry overestimates lOP by as much as 7 mmHg at 30 mmHg.