Flexible coding of time or distance in hippocampal cells.
Flexible coding of time or distance in hippocampal cells.
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DOI：
10.7554/elife.83930
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发表时间：
2023-10-16
期刊：
影响因子：
7.7
通讯作者：
Morris G
中科院分区：
文献类型：
--
作者：
Abramson S;Kraus BJ;White JA;Hasselmo ME;Derdikman D;Morris G
对行为动物海马体中神经元活动的分析揭示了“时间细胞”和“距离细胞”的作用，“时间细胞”在触发事件发生后的特定时间间隔内表现出选择性的峰值模式，“距离细胞”编码特定距离的穿越。其他神经元除了位置选择性外，还表现出这些特征的组合。本研究旨在探讨动物在录音过程中所执行的任务如何影响这些表征的形成。我们分析了Kraus等人2013年进行的跑步机跑步研究的数据，在该研究中，大鼠被训练以不同的速度跑步。这些老鼠被记录在两种试验环境中：一种是“固定时间”条件，动物在跑步机上跑一段预定的时间，然后再继续；另一种是“固定距离”条件，动物在跑步机上跑一段特定的距离。我们的研究结果表明，实验条件的类型显著影响海马细胞的编码。具体来说，距离编码细胞在固定距离实验中占主导地位，而时间编码细胞在固定时间实验中占主导地位。这些结果强调了海马体的灵活编码能力，这是由与奖励条件相关的显著变量的过度表征形成的。
Analysis of neuronal activity in the hippocampus of behaving animals has revealed cells acting as ‘Time Cells’, which exhibit selective spiking patterns at specific time intervals since a triggering event, and ‘Distance Cells’, which encode the traversal of specific distances. Other neurons exhibit a combination of these features, alongside place selectivity. This study aims to investigate how the task performed by animals during recording sessions influences the formation of these representations. We analyzed data from a treadmill running study conducted by Kraus et al., 2013, in which rats were trained to run at different velocities. The rats were recorded in two trial contexts: a ‘fixed time’ condition, where the animal ran on the treadmill for a predetermined duration before proceeding, and a ‘fixed distance’ condition, where the animal ran a specific distance on the treadmill. Our findings indicate that the type of experimental condition significantly influenced the encoding of hippocampal cells. Specifically, distance-encoding cells dominated in fixed-distance experiments, whereas time-encoding cells dominated in fixed-time experiments. These results underscore the flexible coding capabilities of the hippocampus, which are shaped by over-representation of salient variables associated with reward conditions.