Effects of running exercise with increasing loads on tibialis anterior muscle fibres in mice
Effects of running exercise with increasing loads on tibialis anterior muscle fibres in mice
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DOI：
10.1113/eph8702340
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发表时间：
2002-03-01
影响因子：
2.7
通讯作者：
Katsuta, S
中科院分区：
文献类型：
--
作者：
Ishihara, A;Hirofuji, C;Katsuta, S
经过 4 周随负荷增加的自愿跑步锻炼后，检查了小鼠胫骨前肌深部、中部和浅部区域中已确定类型的纤维的横截面积和琥珀酸脱氢酶 (SDH) 活性。十九周大的雄性小鼠被随机分配到对照组或运动组。运动组肌肉表面区域所有类型纤维（IIa、IIx 和 IIb）的平均横截面积均大于对照组。运动组中部区域 IIx 型和 IIb 型纤维以及肌肉浅层区域所有类型（IIa、IIx 和 IIb）纤维的平均 SDH 活性均高于对照组。这些结果表明，随着负荷增加的自愿跑步运动会导致特定肌肉区域的纤维肥大和/或SDH活性增加，该区域分布着具有高阈值和低氧化酶活性的纤维，并且这些纤维被募集以适应运动条件的变化。
Cross-sectional areas and succinate dehydrogenase (SDH) activities of type identified fibres in the deep, middle and superficial regions of the tibialis anterior muscle in mice were examined after 4 weeks of voluntary running exercise with increasing loads. Nineteen-week-old male mice were assigned randomly to either a control or exercise group. The mean cross-sectional areas of all types (IIa, IIx and IIb) of fibres in the superficial region of the muscle were greater in the exercise group than in the control group. The mean SDH activities of type IIx and type IIb fibres in the middle region and of all types (IIa, IIx and IIb) of fibres in the superficial region of the muscle were greater in the exercise group than in the control group. These results suggest that voluntary running exercise with increasing loads causes hypertrophy and/or an increase in the SDH activity of fibres in the specific muscle region where fibres with a high threshold and a low-oxidative enzyme activity are distributed, and these fibres are recruited to adapt to changes in exercise conditions.