Actin machinery: pushing the envelope
Actin machinery: pushing the envelope
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DOI：
10.1016/s0955-0674(99)00063-0
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发表时间：
2000-02-01
影响因子：
7.5
通讯作者：
Svitkina, TM
中科院分区：
文献类型：
--
作者：
Borisy, GG;Svitkina, TM
用纯化的蛋白质在体外重建微生物火箭运动性最近已经明确地确定，不需要肌球蛋白马达的突出。相反，肌动蛋白聚合与少量蛋白质结合就足够了。Arp 2/3复合物控制的成核的树枝状图案为片状脂质体运动提供了有效的推力。
The reconstitution of microbial rocketing motility in vitro with purified proteins has recently established definitively that no myosin motor is required for protrusion. Instead, actin polymerization, in conjunction with a small number of proteins, is sufficient. A dendritic pattern of nucleation controlled by the Arp2/3 complex provides an efficient pushing force for lamellipodial motility.