Ultrathin Two-Dimensional Covalent Organic Framework Nanosheets: Preparation and Application in Highly Sensitive and Selective DNA Detection
Ultrathin Two-Dimensional Covalent Organic Framework Nanosheets: Preparation and Application in Highly Sensitive and Selective DNA Detection
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DOI：
10.1021/jacs.7b04096
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发表时间：
2017-06-28
影响因子：
15
通讯作者：
Zhang, Hua
中科院分区：
文献类型：
--
作者：
Peng, Yongwu;Huang, Ying;Zhang, Hua
高产率制备超薄二维共价有机骨架（COF）纳米片对于进一步探索其独特的性能和潜在的应用前景具有重要意义。本文通过精心设计和选择两个具有C-3分子对称的柔性分子作为构建单元，合成了一种具有六边形层状结构和片状形貌的新型亚胺连接COF，即TPA-COF。由于柔性建筑单元被集成到COF骨架中，层间的堆叠变得很弱，导致TPA-COF容易脱落成超薄的二维NSs。令人印象深刻的是，通过使用最近开发的透射电子显微镜（TEM）低剂量成像技术，首次清晰地显示了NSs中的详细结构信息，即孔隙通道和单个建筑单元。作为概念验证应用，获得的超薄COF NSs被用作高灵敏度和选择性检测DNA的新型荧光传感平台。
The ability to prepare ultrathin two-dimensional (2D) covalent organic framework (COF) nanosheets (NSs) in high yield is of great importance for the further exploration of their unique properties and potential applications. Herein, by elaborately designing and choosing two flexible molecules with C-3, molecular symmetry as building units, a novel imine-linked COF, namely, TPA-COF, with a hexagonal layered structure and sheet-like morphology, is synthesized. Since the flexible building units are integrated into the COF skeletons, the interlayer stacking becomes Weak, resulting in the easy exfoliation of TPA-COF into ultrathin 2D NSs. Impressively, for the first time, the detailed structural information, i.e., the pore channels and individual building units in the NSs, is clearly visualized by using the recently developed low-dose imaging technique of transmission electron microscopy (TEM). As a proof-of-concept application, the obtained ultrathin COF NSs ate used as a novel fluorescence sensing platform for the highly sensitive and selective detection of DNA.