ALPHA-FETOPROTEIN LEVELS IN NORMAL ADULTS
ALPHA-FETOPROTEIN LEVELS IN NORMAL ADULTS
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DOI：
10.1097/00000441-199203000-00004
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发表时间：
1992-03-01
影响因子：
3.1
通讯作者：
ALPERT, E
中科院分区：
文献类型：
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作者：
BALL, D;ROSE, E;ALPERT, E
甲胎蛋白（AFP）是一种胎儿特异性糖蛋白，通常主要由胎儿肝脏产生。正常情况下，AFP水平在出生后迅速下降，在出生后几个月内达到无法检测的水平（< 10 ng/ml）。作者开发了一种更灵敏的放射免疫测定法，使他们能够研究正常成人的低水平AFP，并确定可能影响其正常水平的因素。对270名正常休斯顿献血者进行了筛查，以确定是否存在B型肝炎和ALT水平正常。平均AFP水平为3.04 ng/ml +/- 1.9 SD。在统计学上，男性的水平显著高于女性（p < .004）。回归分析显示，AFP水平随年龄增长在男性（p <0.05）和女性（p <0.01）中均有统计学显著性增加。这些数据描述了美国正常成人血清AFP的正常水平。有了现在确定的正常水平，就有可能比较不同人群的水平，包括接触环境中肝毒素或肝癌物质的人群。
Alpha-fetoprotein (AFP) is a fetal specific glycoprotein normally produced primarily by the fetal liver. Normally, AFP levels decline rapidly after birth, reaching undetectable levels (< 10 ng/ml) within several months after birth. The authors have developed a more sensitive radioimmunoassay, which has allowed them to study low levels of AFP in normal adults and to determine factors which may affect its normal level. Two hundred and seventy normal Houston blood donors were screened for the absence of hepatitis B and normal ALT levels. The mean AFP level was 3.04 ng/ml +/- 1.9 SD. There was a statistically significant higher level in men compared to women (p < .004). Regression analysis demonstrated a statistically significant increase of AFP levels with age both in men (p < .05) and in women (p < .01). These data delineate the normal level of serum AFP in normal adults in the United States. With the normal level now defined, it becomes possible to compare levels in different populations including those exposed to hepatotoxins or hepatocarcinogens in the environment.