The common cold.
The common cold.
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DOI：
10.1016/s0140-6736(03)12162-9
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发表时间：
2003-01-04
期刊：
影响因子：
--
通讯作者：
Järvinen A
中科院分区：
文献类型：
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作者：
Heikkinen T;Järvinen A
尽管医学有了很大的进步，但普通感冒在人类痛苦和经济损失方面仍然是社会的巨大负担。在导致这种疾病的几种病毒中，鼻病毒的作用最突出。大约四分之一的感冒仍没有得到证实的原因，最近发现的人类偏肺炎病毒表明，其他病毒可能仍未被发现。对普通感冒炎症机制的研究阐明了病毒与宿主关系的复杂性。也有越来越多的证据表明，病毒在诱发并发症方面起着核心作用。治疗感冒的新抗病毒药物正在开发中，但这些药物的最佳使用需要快速检测引起感染的特定病毒。尽管也可以获得针对许多呼吸道病毒的疫苗，但最终预防普通感冒似乎仍然是一个遥远的目标。
Despite great advances in medicine, the common cold continues to be a great burden on society in terms of human suffering and economic losses. Of the several viruses that cause the disease, the role of rhinoviruses is most prominent. About a quarter of all colds are still without proven cause, and the recent discovery of human metapneumovirus suggests that other viruses could remain undiscovered. Research into the inflammatory mechanisms of the common cold has elucidated the complexity of the virus-host relation. Increasing evidence is also available for the central role of viruses in predisposing to complications. New antivirals for the treatment of colds are being developed, but optimum use of these agents would require rapid detection of the specific virus causing the infection. Although vaccines against many respiratory viruses could also become available, the ultimate prevention of the common cold seems to remain a distant aim.