First-degree family history of diabetes and its relationship with serum osteocalcin levels independent of liver fat content in a non-diabetic Chinese cohort
First-degree family history of diabetes and its relationship with serum osteocalcin levels independent of liver fat content in a non-diabetic Chinese cohort
复制标题
中国非糖尿病队列中糖尿病一级家族史及其与血清骨钙素水平的关系（独立于肝脏脂肪含量）
DOI：
10.1186/s12889-019-7932-5
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发表时间：
2019-12-03
影响因子：
4.5
通讯作者：
Bao，Yuqian
中科院分区：
文献类型：
--
作者：
Xu，Yiting;Shen，Yun;Bao，Yuqian
背景糖尿病患者（FDR）的一级亲属往往有胰岛素活性受损，这导致循环细胞因子水平的改变。肝脏是胰岛素作用的主要靶组织；因此，肝脏脂肪含量（LFC）与胰岛素抵抗密切相关。本研究旨在发现FDR患者血清骨钙素水平的变化，以及血清骨钙素水平与FDR和非酒精性脂肪性肝病（NAFLD）的关系。方法共纳入1206例受试者，其中男性413例，女性793例，来自社区，年龄59.7岁（范围54.8 ~ 64.3岁）。电化学发光免疫法测定血清骨钙素水平。定量超声测量LFC。结果NAFLD组和FDR组血清骨钙素水平均显著降低（19.8±5.7 ng/mL vs 20.7±6.8 ng/mL，P= 0.028）。此外，在NAFLD患者中，FDR患者的骨钙素水平低于未FDR患者（P= 0.011）。在调整体重指数、血糖、血脂和LFC后，FDR的存在仍然是血清骨钙素水平降低的预测因子（标准化β= - 0.057，P= 0.028）。结论fdr患者血清骨钙素水平低于非fdr患者。FDR和血清骨钙素水平之间的负相关与代谢因素无关。
BackgroundFirst-degree relatives of patients with diabetes (FDR) tend to have impaired insulin activity, which lead to the alternation of circulating cytokine levels. Liver is a main target tissue of insulin action; therefore, liver fat content (LFC) has a close relationship with insulin resistance. This study aimed to find the alteration in serum osteocalcin levels in FDR and the relationship of serum osteocalcin levels with FDR and non-alcoholic fatty liver disease (NAFLD).MethodsIn total, 1206 subjects including 413 men and 793 women from the communities, aged 59.7 (range, 54.8–64.3) years, were enrolled. An electrochemiluminescence immunoassay was performed to measure the levels of serum osteocalcin. LFC was measured using quantitative ultrasonography.ResultsA significant decrease was found in serum osteocalcin levels in subjects with NAFLD (P< 0.001) as well as in FDR (19.8 ± 5.7 ng/mL versus 20.7 ± 6.8 ng/mL,P= 0.028). Furthermore, among the subjects with NAFLD, those with FDR had lower levels of osteocalcin than those without FDR (P= 0.011). The presence of FDR remained a predictor for decreased serum osteocalcin levels after adjusting for body mass index, blood glucose, blood lipids, and LFC (standardizedβ= − 0.057,P= 0.028).ConclusionsFDR had lower serum osteocalcin levels than non-FDR. The inverse association between FDR and serum osteocalcin levels was independent of metabolic factors.