Haemolytic-Uraemic Syndrome in Typhoid Fever
Haemolytic-Uraemic Syndrome in Typhoid Fever
复制标题
伤寒溶血尿毒症综合征
DOI：
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发表时间：
1974
影响因子：
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通讯作者：
Physician J. E. P. Thomas
中科院分区：
文献类型：
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作者：
M. B. N. M. BAKER;M. B. A. E. MILLS;Pathologist I. Rachman;Physician J. E. P. Thomas
在48例伤寒感染患者中，6例（12.5%）发生溶血性尿毒综合征。无论是葡萄糖-6-磷酸脱氢酶缺乏症或氯霉素治疗都不能作为致病因素。这里提出的证据表明，其机制是局部血管内凝血。伤寒时出现白细胞增多提示有并发症，应警惕溶血性尿毒综合征的可能。此外，在我们地区，伤寒应被怀疑为任何急性肾衰竭患者的病因。
Among 48 patients with a typhoid infection 6 (12·5%) developed the haemolytic-uraemic syndrome. Neither glucose-6-phosphate dehydrogenase deficiency nor therapy with chloramphenicol could be incriminated as the causal factor. Evidence presented here suggests that the mechanism is localized intravascular coagulation. The presence of leucocytosis in typhoid fever suggests a complication and should alert one to the possibility of the haemolytic-uraemic syndrome. Furthermore, in our area typhoid should be suspected as a cause in any patient presenting with acute renal failure.