CORRELATION OF LIGHT-INDUCED-CHANGES IN RETINAL EXTRACELLULAR POTASSIUM CONCENTRATION WITH C-WAVE OF ELECTRORETINOGRAM
CORRELATION OF LIGHT-INDUCED-CHANGES IN RETINAL EXTRACELLULAR POTASSIUM CONCENTRATION WITH C-WAVE OF ELECTRORETINOGRAM
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DOI：
10.1152/jn.1976.39.5.1117
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发表时间：
1976-01-01
影响因子：
2.5
通讯作者：
GREEN, DG
中科院分区：
文献类型：
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作者：
OAKLEY, B;GREEN, DG
1.双桶，钾特定的微电极已被用来测量光诱导的瞬态变化[K+]O在蛙眼杯制备。[K+]o的这些变化被称为钾视网膜图（KRG）。2. KRG由两个部分组成：近端视网膜中[K+]o的快速增加和远端视网膜中[K+]o的缓慢减少。3. KRG减少具有视紫红质作用谱，在感光层中最大，在天冬氨酸处理后持续存在，并且具有在中等背景强度下饱和的增量阈值曲线。因此，视紫红质视杆细胞很可能是产生这种离子变化的唯一神经元，尽管Muller（神经胶质）细胞也可能参与这一过程。4.对于刺激参数的所有变化，包括强度、持续时间和色度，KRG降低具有与视网膜电图的c波相同的时间过程。5.这表明C波可能是由色素上皮细胞对感光细胞周围[K+]o减少的反应而产生的。
1. Double-barrel, potassium-specific microelectrodes have been used to measure light-induced transient changes in [K+]o in the frog eye cup preparation. These changes in [K+]o have been termed the potassioretinogram (KRG). 2. The KRG consists of two components: a rapid increase in [K+]o in the proximal retina and a slow decrease in [K+]o in the distal retina. 3. The KRG decrease has the rhodopsin action spectrum, is maximal in the photoreceptor layer, persists after aspartate treatment, and has an increment threshold curve which saturates at moderate background intensities. The rhodopsin rods are, therefore, most likely the only neurons which generate this ionic change, although the Muller (glial) cells may also be involved in this process. 4. The KRG decrease has the same time course as the c-wave of the electroretinogram for all variations in the stimulus parameters, including intensity, duration, and chromaticity. 5. It is suggested that the c-wave may be produced by the pigment epithelial cells as they hyperpolarize in response to the decrease in [K+]o around the photoreceptors.